Untersuchungen zur differentiellen Bedeutung des adaptiven Immunsystems für die FAA-induzierte Hepatitis und Hepatokarzinogenese

适应性免疫系统对 FAA 诱导的肝炎和肝癌发生的不同重要性的研究

• 批准号: 205673010
• 负责人: Professor Dr. Arndt Vogel
• 金额: --
• 依托单位: Klinik für Gastroenterologie, Hepatologie und Endokrinologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/205673010?language=en
• 关键词: Untersuchungen; zur; differentiellen; Bedeutung; des

Tumors often arise at sites of inflammation and chronic inflammation is increasingly recognized to be important in the pathogenesis of many malignancies. Each stage of malignancies appears to be exquisitely susceptible to regulation of immune cells. Activation of the adaptive immune system in response to tumors might result in eradication of malignant cells. On the other hand, immune cells, which infiltrate tumors and pre-neoplastic lesions, produce a variety of cytokines and chemokines that propagate a localized inflammatory response and that can also enhance the growth and survival of premalignant cells. Hepatocellular carcinoma, which is one of the most lethal and prevalent cancers worldwide, represents a classic case of inflammation-linked cancer. There is increasing evidence indicating that the immune system contributes to heptocarcinogenesis. Understanding the molecular mechanisms underlying the tumor promoting properties of the immune system is critical to any effort to slow down hepatocarcinogenesis by either bolstering anti-tumor responses or by neutralizing cancer-promoting properties of immune cells. The aim of our study is to define the role of the immune system for tumor development in the liver during chronic injury. Our longterm aim is to find novel treatment strategies through pharmacologic activation or inactivation of key oncogenic pathways to prevent or at least delay liver tumor development.

肿瘤通常发生在炎症部位，人们越来越认识到慢性炎症在许多恶性肿瘤的发病机制中很重要。恶性肿瘤的每个阶段似乎都非常容易受到免疫细胞调节的影响。针对肿瘤的适应性免疫系统的激活可能会导致恶性细胞的根除。另一方面，浸润肿瘤和肿瘤前病变的免疫细胞产生多种细胞因子和趋化因子，传播局部炎症反应，并且还可以增强癌前细胞的生长和存活。肝细胞癌是全世界最致命和最常见的癌症之一，是炎症相关癌症的典型病例。越来越多的证据表明免疫系统有助于肝癌的发生。了解免疫系统促癌特性背后的分子机制对于通过增强抗肿瘤反应或中和免疫细胞促癌特性来减缓肝癌发生的任何努力至关重要。我们研究的目的是确定免疫系统在慢性损伤期间肝脏肿瘤发展中的作用。我们的长期目标是通过药理学激活或灭活关键致癌途径来寻找新的治疗策略，以预防或至少延缓肝脏肿瘤的发展。