Untersuchungen zur differentiellen Bedeutung des adaptiven Immunsystems für die FAA-induzierte Hepatitis und Hepatokarzinogenese

适应性免疫系统对 FAA 诱导的肝炎和肝癌发生的不同重要性的研究

• 批准号: 205673010
• 负责人: Professor Dr. Arndt Vogel
• 金额: --
• 依托单位: Klinik für Gastroenterologie, Hepatologie und Endokrinologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/205673010?language=en
• 关键词: Untersuchungen; zur; differentiellen; Bedeutung; des

Tumors often arise at sites of inflammation and chronic inflammation is increasingly recognized to be important in the pathogenesis of many malignancies. Each stage of malignancies appears to be exquisitely susceptible to regulation of immune cells. Activation of the adaptive immune system in response to tumors might result in eradication of malignant cells. On the other hand, immune cells, which infiltrate tumors and pre-neoplastic lesions, produce a variety of cytokines and chemokines that propagate a localized inflammatory response and that can also enhance the growth and survival of premalignant cells. Hepatocellular carcinoma, which is one of the most lethal and prevalent cancers worldwide, represents a classic case of inflammation-linked cancer. There is increasing evidence indicating that the immune system contributes to heptocarcinogenesis. Understanding the molecular mechanisms underlying the tumor promoting properties of the immune system is critical to any effort to slow down hepatocarcinogenesis by either bolstering anti-tumor responses or by neutralizing cancer-promoting properties of immune cells. The aim of our study is to define the role of the immune system for tumor development in the liver during chronic injury. Our longterm aim is to find novel treatment strategies through pharmacologic activation or inactivation of key oncogenic pathways to prevent or at least delay liver tumor development.

肿瘤通常在炎症部位出现，慢性炎症越来越被认为在许多恶性肿瘤的发病机理中很重要。恶性肿瘤的每个阶段似乎都非常容易受到免疫细胞的调节。自适应免疫系统响应肿瘤的激活可能导致根除恶性细胞。另一方面，浸润肿瘤和肿瘤前病变的免疫细胞会产生各种细胞因子和趋化因子，这些细胞因子和趋化因子传播局部炎症反应，并且还可以增强预抗细胞的生长和存活。肝细胞癌是全球最致命和流行的癌症之一，代表了与炎症相关的癌症的经典病例。有越来越多的证据表明免疫系统有助于甲状腺激素发生。了解免疫系统肿瘤促进特性的分子机制对于通过增强抗肿瘤反应或中和免疫细胞中和促进癌症特性来减慢肝癌的努力至关重要。我们研究的目的是定义免疫系统在慢性损伤过程中肿瘤发育的作用。我们的长期目的是通过药物激活或灭活关键致癌途径来预防或至少延迟肝肿瘤发育的新治疗策略。