Physically decoupling neural recording sites in behaving animals

物理解耦行为动物的神经记录位点

基本信息

批准号：
1146243
负责人：
Aaron Redish
金额：
$ 60万
依托单位：
University of Minnesota-Twin Cities
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2012
资助国家：
美国
起止时间：
2012-04-15 至 2015-03-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1146243&HistoricalAwards=false
关键词：
Physically decoupling neural recording sites

项目摘要

Implantable devices for physiological monitoring are in common use in both clinical and research settings. Even the most advanced current technologies, however, have limitations due to the need to connect a wire to the recording site. For example, these systems have particular difficulty recording from moving or fragile structures (such as the spinal cord) because wire electrodes shred fragile nerves as the animal moves. Similarly, it has been difficult to record from freely behaving small animals, particularly those without strong skeletons (leeches, fish). We have developed a new technology that does not have these technical limitations. This technology has been tested, and we are now moving it into working neuroscience laboratories. Consequently this project includes collaboration between researchers at the University of Minnesota (a major research university) and St. Olaf College (a liberal arts college) and will provide opportunities for development in graduate and undergraduate research and teaching. Our probe devices can be built extremely cheaply, either hand-built individually by an undergraduate or built en-masse through integrated circuit production. The technology we have developed will be of extraordinary use both in research (due to the ability to record from novel preparations) and in teaching (due to its simplicity, reliability, and low cost).

用于生理监测的可植入设备在临床和研究环境中均常用。但是，由于需要将电线连接到录音站点，即使是最先进的当前技术也有局限性。例如，这些系统在移动或脆弱的结构（例如脊髓）中记录特别困难，因为当动物移动时，电线电极切碎了脆弱的神经。同样，很难从自由行为的小动物（尤其是那些没有强骨的人（水ches，鱼））中记录记录。我们已经开发了一种没有这些技术限制的新技术。该技术已经进行了测试，我们现在正在将其转移到工作的神经科学实验室中。因此，该项目包括明尼苏达大学（一所主要研究学院）和圣奥拉夫学院（一所文科学院）的研究人员之间的合作，并将为研究生和本科研究和教学提供发展机会。我们的探测设备可以非常便宜地建造，要么是由本科生或通过集成电路生产来单独制造的。我们开发的技术将在研究中具有非凡的用途（由于能够从新颖的准备工作中记录）和教学（由于其简单，可靠性和低成本）。