Studies of New Ionization Approaches in Mass Spectrometry for Imaging

成像质谱新电离方法的研究

• 批准号: 1112289
• 负责人: Charles McEwen
• 金额: $ 34.5万
• 依托单位: University of the Sciences in Philadelphia
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-15 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1112289&HistoricalAwards=false
• 关键词: Studies; New; Ionization; Approaches; Mass

With support from the Chemical Measurement and Imaging Program, Professor Charles N. McEwen of the University of the Sciences seeks improved understanding of certain newly developed mass spectrometric (MS) ionization methods, with aims of improving reproducibility and sensitivity. These ionization methods (discovered in collaboration with Professor Sarah Trimpin of Wayne State University) have attributes of both matrix assisted laser desorption/ionization (MALDI) and electrospray ionization (ESI). They each produce multiply charged ions, similar to ESI, allowing analysis of high mass compounds and enhancing utility of ion mobility techniques. Increasing the sensitivity and reproducibility of these new ionization methods may make possible high spatial resolution imaging under atmospheric conditions. Areas requiring high throughput analyses (such as consumer protection, counter-terrorism, environmental monitoring, clinical applications, and biological materials analysis) will be impacted by these developments. The broad training gained by the graduate and undergraduate students involved will enhance their future scientific potential.

在化学测量和成像计划的支持下，科学大学的Charles N. McEwen教授寻求对某些新开发的质谱法（MS）电离方法的了解，其目的是提高可重复性和敏感性。 这些电离方法（与韦恩州立大学的Sarah Trimpin教授合作发现）具有矩阵辅助激光解吸/电离（MALDI）和电喷雾电离（ESI）的属性。 它们各自产生与ESI相似的乘电离子，从而可以分析高质量化合物并增强离子迁移率技术的效用。提高这些新电离方法的敏感性和可重复性可能会使大气条件下的高空间分辨率成像。 需要高通量分析的领域（例如消费者保护，反恐，环境监测，临床应用和生物材料分析）将受到这些发展的影响。 研究生和本科生所获得的广泛培训将增强其未来的科学潜力。