Vapor Treatment of Charged Droplets for Enhanced Electrospray Ionization Performance

带电液滴的蒸气处理以增强电喷雾电离性能

• 批准号: 1111389
• 负责人: Scott McLuckey
• 金额: $ 39万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1111389&HistoricalAwards=false
• 关键词: Vapor; Treatment; Charged; Droplets; Enhanced

Prof. Scott McLuckey at Purdue University is supported by the Chemical Measurement and Imaging Program for investigations aimed at expanding analytical capabilities of mass spectrometry via novel approaches to gas-phase ion formation and transformation. Mass spectrometry is a powerful means of characterizing the mass and structure of gaseous ions. Dr. McLuckey is exploring novel approaches for generating gaseous ions based on exposing charged droplets and/or clusters to reactive vapors. Altering the chemical environment in charged droplets can have dramatic effects on the observed mass spectra, with respect both to ionization efficiency and ion-type. This work will add to the range of options available to manipulate analyte species for subsequent mass spectrometric analysis because it represents an approach that is intermediate between the bulk condensed-phase and the gas-phase. This work has significant potential for expanding and improving the performance and applicability of mass spectrometry. The work is highly multi-disciplinary, and exposes students to ion physics, ion chemistry, instrumentation, and analytical chemistry, in addition to issues specific to the measurement challenge (e.g., pharmaceutical analysis, biomarker detection, protein interaction research, etc.).

普渡大学的斯科特·麦克卢（Scott McLuckey）教授得到了化学测量和成像计划的支持，该计划旨在通过新颖的方法来扩大质谱分析能力，这是通过新颖的燃气离子形成和转化的方法。 质谱法是表征气态离子质量和结构的强大手段。 McLuckey博士正在探索基于将带电的液滴和/或簇产生气体离子的新方法，以产生反应性蒸气。 相对于电离效率和离子类型，改变带电的液滴中的化学环境可能会对观察到的质谱产生巨大影响。 这项工作将增加可用于操纵分析物物种的选项范围，以进行随后的质谱分析，因为它代表了一种中间的方法，该方法介于整体冷凝相和气相之间。 这项工作具有扩大和提高质谱的性能和适用性的巨大潜力。 这项工作是高度多学科的，除了针对测量挑战的特定问题（例如，药物分析，生物标志物检测，蛋白质相互作用研究等）外，还使学生接受了离子物理，离子化学，仪器和分析化学的离子物理学，离子化学，仪器和分析化学。