Collaborative Research: Biological Shape Spaces, Transforming Shape into Knowledge

合作研究：生物形状空间，将形状转化为知识

• 批准号: 1053171
• 负责人: Cindy Grimm
• 金额: $ 21.39万
• 依托单位: Washington University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-15 至 2013-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1053171&HistoricalAwards=false
• 关键词: Collaborative; Research; Biological; Shape; Spaces

Collaborative Research: Biological Shape Spaces, Transforming Shape into KnowledgeThis project will develop a framework to represent, analyze and interpret shapes extracted from images, supporting a wide range of biological investigations. The primary objectives are: (1) to develop a mathematical framework and computational tools for the quantification and analysis of shapes; (2) to integrate these computational models with machine learning and statistical inference methods to enable new discoveries, transforming imaging data into biological knowledge; (3) to deliver novel quantitative methodologies for shape analysis that start from a biological premise, rather than a purely geometric one. The aim is thus not only to quantitatively describe shape, but to develop methods for linking morphological variation to its underlying biological causes. To ensure that the project focuses on methods that are most promising to biology with significant breadth of application, model and tool development will be guided and supported by a set of diverse case studies, ranging from the sub-cellular to organismal scales. Shape represents a complex and rich source of biological information that is fundamentally linked to underlying mechanisms and function. However, shape is still often examined on a qualitative basis in many disciplines in biology, an approach that is time consuming and prone to human subjectivity. While ad hoc quantitative methods do exist, they are often inaccessible to non-experts and do not easily generalize to a wide variety of problems. The inability of biologists to systematically link shape to genetics, development, environment, function and evolution often precludes advances in biological research spanning diverse spatial and temporal scales, from the movement of molecules within a cell to adaptive changes in organismal morphology. The primary goal of this project is to develop a new suite of widely applicable quantitative methods and tools into the study of biological shape to address the significant need for consistent and repeatable analysis of shape data.

合作研究：生物形状空间，将形状转化为知识该项目将开发一个框架来表示、分析和解释从图像中提取的形状，支持广泛的生物研究。主要目标是：（1）开发用于形状量化和分析的数学框架和计算工具； （2）将这些计算模型与机器学习和统计推断方法相结合，以实现新的发现，将成像数据转化为生物知识； (3) 为形状分析提供新颖的定量方法，该方法从生物学前提开始，而不是纯粹的几何前提。因此，目的不仅是定量描述形状，而且是开发将形态变异与其潜在生物学原因联系起来的方法。 为了确保该项目重点关注对生物学最有前景且应用广泛的方法，模型和工具开发将得到一系列从亚细胞到生物尺度的不同案例研究的指导和支持。形状代表了复杂而丰富的生物信息源，与潜在的机制和功能有着根本的联系。然而，在生物学的许多学科中，形状仍然经常在定性的基础上进行检查，这种方法既耗时又容易受到人类主观性的影响。虽然确实存在临时定量方法，但非专家通常无法使用它们，并且不容易推广到各种问题。生物学家无法系统地将形状与遗传学、发育、环境、功能和进化联系起来，这常常阻碍了跨越不同空间和时间尺度的生物学研究的进展，从细胞内分子的运动到生物体形态的适应性变化。该项目的主要目标是开发一套新的广泛适用的定量方法和工具来研究生物形状，以满足对形状数据进行一致和可重复分析的重大需求。