RCN: Phenotype Ontology Research Coordination Network

RCN：表型本体研究协调网络

• 批准号: 0956049
• 负责人: Wasila Dahdul
• 金额: $ 49.87万
• 依托单位: University of South Dakota Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-10-01 至 2016-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0956049&HistoricalAwards=false
• 关键词: RCN; Phenotype; Ontology; Research; Coordination

Knowledge of how an organism looks, behaves and functions, i.e., its "phenotype", is central to interpreting the interaction of underlying genes and environmental effects. Representing phenotype in a way that can be linked to thousands of molecular genetic and environmental databases, however, remains difficult. The goal of this project is to establish a network of experts on plant and animal phenotypes and on computer representation methods (ontologies) from communities that are independently developing ways to represent and share phenotypic data. Through this Research Coordination Network, scientists will be brought together and their activities coordinated to: (1) develop standards and best practices for accurate phenotype representations; (2) build key reference ontologies for plants, vertebrates, and arthropods; and (3) cross reference these ontologies so that key data can be easily shared and accessed. Coordinating scientific efforts so that effective linkages are built into databases from the outset is an efficient and economical mechanism to develop a data network. Plants and animals show complex integration across genes, phenotype and environment, and a network of these data will enable rapid scientific discovery and progress. This project also will reach out to scientists who can use the data, help them link to it, and educate their communities about these computational methods and their utility.

了解生物体的外观，行为和功能，即其“表型”，对于解释基本基因和环境影响的相互作用至关重要。 然而，以与数千个分子遗传和环境数据库相关的方式表示表型仍然很困难。该项目的目的是建立一个针对动植物表型的专家网络以及来自社区的计算机代表方法（本体），这些方法正在独立开发代表和共享表型数据的方式。通过这个研究协调网络，科学家将聚集在一起，他们的活动协调为：（1）为准确的表型表示制定标准和最佳实践； （2）为植物，脊椎动物和节肢动物建立关键的参考本体论； （3）交叉引用这些本体，以便可以轻松共享和访问关键数据。协调科学努力，以便从一开始就将有效的联系内置到数据库中，这是开发数据网络的有效且经济的机制。植物和动物在基因，表型和环境之间表现出复杂的整合，这些数据的网络将实现快速的科学发现和进步。该项目还将与可以使用数据，帮助他们链接到的科学家联系，并就这些计算方法及其效用进行教育。