SBIR Phase I: Hand-Held Device for PPB-level Water Analysis

SBIR 第一阶段：用于 PPB 级水分析的手持设备

• 批准号: 0945002
• 负责人: Mark Peterman
• 金额: --
• 依托单位: OndaVia, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0945002&HistoricalAwards=false
• 关键词: SBIR; Phase; Hand; Held; Device

This SBIR Phase I project will develop a unique "lab-on-a-chip", with the objective to be able to simultaneously detect several water contaminants down to parts-per-billion levels. The separation method to be used is an innovative microfluidics undulating electro-osmosis technique which uses a capillary tube with a varying diameter. The detector is a surface-enhanced Raman spectrophotometer using embedded metallic nanoparticles. The project team will conduct tests of the instrument using perchlorate and nicotine as the target species for testing. These target species are to be adsorbed onto gold nanoparticles.The broader/commercial impact of the proposed project will be that this could lead to the capability of detecting a broad array of contaminants in the natural environment such as emerging pharmaceuticals, arsenic, heavy metals, melanine, plasticizers, etc. Contaminants of national security risk would be additional targets. Labs-on-a-chip have been developed and commercialized by several companies, but in general they are limited to basic analyses such as pH, conductivity, etc., and/or they can detect specific organic or inorganic compounds only to parts per million levels. Being able to go down to parts per billion levels will be a great benefit for numerous applications such as on-site investigations. Coupling the novel separation technique to the surface-enhanced Raman spectrophotometer could result in a unique technology that could be quite useful for detecting and quantifying many chemical species in water.

这个SBIR I期项目将开发出独特的“芯片实验室”，目的是能够同时检测到每亿少数水平的几种水污染物。 要使用的分离方法是一种创新的微流体，起伏的电渗透技术，该技术使用直径变化的毛细管。 检测器是使用嵌入式金属纳米颗粒的表面增强的拉曼分光光度计。 项目团队将使用高氯酸盐和尼古丁作为测试的目标物种进行仪器测试。 这些目标物种将被吸附到金纳米颗粒上。拟议项目的更广泛/商业影响是，这可能会导致能力在自然环境中检测出广泛的污染物，例如新兴的药品，砷，重金属，厚金属，黑色素，塑料等的污染物等于其他目标。芯片上的实验室已经由几家公司开发和商业化，但总的来说，它们仅限于pH，电导率等基本分析和/或它们可以检测到特定的有机或无机化合物，仅到每百万级别的零件。 对于诸如现场调查之类的众多应用程序，能够降低到十亿级的零件将是一个很大的好处。 将新颖的分离技术与表面增强的拉曼分光光度计结合起来可能会导致独特的技术，该技术对于检测和量化水中的许多化学物种非常有用。