IDR - Enhanced Near-Infrared Monitoring of Brain Function in Infants

IDR - 增强婴儿大脑功能的近红外监测

• 批准号: 0931687
• 负责人: Andrew Berger
• 金额: $ 36.54万
• 依托单位: University of Rochester
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0931687&HistoricalAwards=false
• 关键词: IDR; Enhanced; Near; Infrared; Monitoring

0931687BergerThis project aims to improve the use of near-infrared light for studying infants' brain activity. Although current optical methods of monitoring brain activity in infants show promise, many poorly-corrected variables (physical, physiological, and anatomical) still corrupt the data from too many infant participants. Through the research team's combination of expertise in biophotonics, brain and cognitive sciences, and pediatrics, the sources of noise will be reduced to levels where meaningful scans can be performed on babies routinely. The method used will be near-infrared spectroscopy (NIRS), which measures changes in the absorption of light by blood in the scalp and brain. The instrumentation will include dedicated "scalp-only" channels whose source-detector separations (~5 mm) are too short to be sensitive to brain signals. When one of these channels' readout is subtracted from standard channels (with separations of 20-35 mm), much physiological noise is cancelled, and stimulus related activations become easier to observe. The researchers' home-built corrected-near infrared-spectroscopy (C-NIRS) system for adults will be restructured for infant studies and enhanced with more sources and detectors, enabling measurements from a stimulated region and concurrent monitoring of a "control" region. An instrument of this scale designed with dedicated near-channel noise-suppression will be the first of its kind. In parallel, a more flexible silicone-based headband will be developed to fit a range of head shapes, be comfortable and safe for infants, and reduce the amplitude of motion artifacts in the data. The new instrument will be tested on a cohort of 60 healthy, alert infant participants (age 6-9 mos.), along with a commercial near-infrared instrument that lacks correction channels.Measurement protocols will focus on well-studied visual and auditory stimulation paradigms. The reductions in physiological noise and motion artifacts should yield a higher "hit rate" of meaningful data runs using the C-NIRS instrument than for traditional NIRS, thereby establishing C-NIRS as a valuable tool in the arsenal of the cognitive scientist studying infant development.

0931687Berger该项目旨在改善近红外光在研究婴儿大脑活动中的使用。尽管目前监测婴儿大脑活动的光学方法显示出希望，但许多校正不佳的变量（物理、生理和解剖学）仍然破坏了太多婴儿参与者的数据。通过研究团队结合生物光子学、大脑和认知科学以及儿科方面的专业知识，噪音源将减少到可以对婴儿进行常规扫描的水平。使用的方法是近红外光谱（NIRS），它可以测量头皮和大脑中血液吸收光的变化。该仪器将包括专用的“仅限头皮”通道，其源探测器间距（约5毫米）太短而无法对大脑信号敏感。当从标准通道（间隔为 20-35 毫米）中减去这些通道之一的读数时，许多生理噪音被消除，并且与刺激相关的激活变得更容易观察。研究人员自制的成人校正近红外光谱（C-NIRS）系统将针对婴儿研究进行重组，并通过更多光源和探测器进行增强，从而能够从刺激区域进行测量并同时监测“控制”区域。具有专用近通道噪声抑制功能的这种规模的仪器将是同类中的第一个。与此同时，我们还将开发一种更灵活的硅胶头带，以适应各种头部形状，让婴儿舒适安全，并减少数据中运动伪影的幅度。新仪器将在 60 名健康、警觉的婴儿参与者（6-9 个月）以及缺乏校正通道的商用近红外仪器上进行测试。测量方案将侧重于经过充分研究的视觉和听觉刺激范式。与传统 NIRS 相比，生理噪声和运动伪影的减少应该会产生使用 C-NIRS 仪器运行的有意义数据的“命中率”更高，从而使 C-NIRS 成为认知科学家研究婴儿发育的重要工具。 。