BYPASS1 root-to-shoot signaling: the mobile signal interacts with the auxin pathway

BYPASS1 根到芽信号传导：移动信号与生长素途径相互作用

• 批准号: 0922288
• 负责人: Leslie Sieburth
• 金额: $ 25万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0922288&HistoricalAwards=false
• 关键词: BYPASS1; root; shoot; signaling; mobile

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).Leslie E. SieburthIOS 0922288BYPASS1 root-to-shoot signaling: the mobile signal interacts with the auxin pathwayPlants develop in an integrated manner, even though root and shoot systems are separated spatially and perceive different environmental conditions. For example, roots directly detect the soil compaction or drought, but unfavorable conditions also lead to altered shoot development. Physiological studies have shown that roots produce signaling molecules that move to the shoot, but how these signaling molecules modify shoot development is unknown. This project will investigate how shoot development is modulated by a root-derived long distance signal that is over-produced in Arabidopsis bypass1 mutants. This root-derived substance arrests leaf development. Recent data suggest that growth restriction occurs by reducing responses to auxin, an important plant hormone. The investigators will use molecular and physiological approaches to investigate hormone responses. Specific steps of the auxin response pathway will be analyzed using genetic and biochemical tools. This research program will reveal mechanistic detail of root-sourced signal interaction with auxin. Root-derived signals that limit shoot growth impose severe reductions in agriculture. Understanding of how shoot development programs are regulated by root-derived signals could lead to alternative agricultural practices that maximize productivity. Broader impacts of this work are scientific (advancing our knowledge of signaling pathways, to be shared through publications and talks at conferences) and educational. Two undergraduate students, one from an under-served background, will be trained in genetics and molecular biology. One postdoctoral scholar will receive communication and teaching training. The postdoc and undergraduates will work together to develop a laboratory exercise for an undergraduate developmental biology class. This lab will provide hands-on experience with long distance signaling, and will be disseminated widely.

该奖项是根据2009年的《美国回收与再投资法》（公法111-5）进行的。LESLIEE. SIEBURTHIOS 0922288BYPASS1根到脚射击信号：即使根和射击系统在空间和分离的环境中分离出来，移动信号与生长素途径与生长素途径相互作用。 例如，根直接检测到土壤压实或干旱，但不利的条件也会导致芽的发展改变。 生理研究表明，根会产生移动到芽的信号分子，但是这些信号分子如何改变芽的发育尚不清楚。 该项目将调查芽的发育如何通过拟南芥旁路1突变体中过量生产的根衍生的长距离信号调节。 这种根源的物质逮捕了叶子的发育。 最近的数据表明，生长限制是通过减少对生长素的反应，这是一种重要的植物激素。 研究人员将使用分子和生理方法研究激素反应。 将使用遗传和生化工具分析生长素反应途径的特定步骤。 该研究计划将揭示根源信号相互作用与生长素的机理细节。 限制射击生长的根源信号会严重减少农业。 了解射击开发计划如何受根衍生的信号调节可能会导致最大化生产力的替代农业实践。 这项工作的更广泛的影响是科学的（推进了我们对信号通路的了解，通过会议上的出版物和谈判分享）和教育。 两名来自服务不足的本科生将接受遗传学和分子生物学的培训。 一位博士后学者将接受沟通和教学培训。 博士后和本科生将共同为本科生物学课程开发实验室演习。 该实验室将提供长途信号的动手体验，并将被广泛传播。