RUI: Microfluidic Impedance Spectroscopy for Cellular Electrical Property Analysis

RUI：用于细胞电特性分析的微流控阻抗谱

• 批准号: 0916138
• 负责人: Liju Yang
• 金额: $ 14.32万
• 依托单位: North Carolina Central University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0916138&HistoricalAwards=false
• 关键词: RUI; Microfluidic; Impedance; Spectroscopy; Cellular

0916138YangThis NSF award by the Biosensing /CBET program supports work by Professor Liju Yang at North Carolina Central University (NCCU) to study the electrical properties of cancer cells in comparison with normal epithelial cells. A microfluidic chip with featured microelectrodes will be designed and developed to carry out this study. The microchip will use dielectrophresis to capture cells onto the microelectrodes. The captured cells will subsequently be studied in a wide frequency range using electrical impedance spectroscopy, and their electrical properties will be analyzed using proper equivalent circuit models. This research will provide a direct (without biomarkers) approach to distinguish cancer cells from normal cells. It has potential applications in early diagnosis of cancer and monitoring of cancer metastasis and the progress of cancer treatment. Education will include the incorporation of research into course development and the training of minority undergraduate students at NCCU in interdisciplinary research.

0916138Yang 这项由生物传感/CBET 项目颁发的 NSF 奖项支持北卡罗来纳中央大学 (NCCU) 的 Liju Yang 教授研究癌细胞与正常上皮细胞相比的电特性。将设计和开发具有特色微电极的微流控芯片来进行这项研究。微芯片将使用介电泳将细胞捕获到微电极上。随后将使用电阻抗光谱在宽频率范围内研究捕获的细胞，并使用适当的等效电路模型分析它们的电特性。这项研究将提供一种直接（无需生物标志物）的方法来区分癌细胞与正常细胞。它在癌症的早期诊断、监测癌症转移和癌症治疗进展方面具有潜在的应用。教育将包括将研究纳入课程开发，以及对国立政治大学少数民族本科生进行跨学科研究的培训。