Loss and rescue of regeneration in naidine annelids

环节动物再生能力的丧失与挽救

• 批准号: 0920502
• 负责人: Alexandra Bely
• 金额: $ 45万
• 依托单位: University of Maryland, College Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0920502&HistoricalAwards=false
• 关键词: Loss; rescue; regeneration; naidine; annelids

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). Animals vary tremendously in their ability to replace lost body parts. While some animals, such as humans, cannot re-grow most body parts, others, such as some segmented worms, can re-grow an entire body from a small fragment of the original animal. The ultimate goal of this research is to understand the root causes of this variation and to identify factors that can cause regeneration, the process of body part replacement, to fail or proceed. Specifically, this work focuses on two closely related species of segmented worms, one that can regenerate its head and the other that cannot do so except when the cut occurs within developmentally very young tissue. Investigations in these two species will identify genes and developmental processes that may allow an animal to regenerate even when it usually cannot do so. Determining the specific conditions under which regeneration can be elicited in an otherwise non-regenerating species will further understanding of the natural blocks to successful regeneration and suggest paths to circumventing these blocks. This work will foster the training of a diverse group of undergraduate, graduate, and post-graduate researchers within an environment highly supportive of strong mentoring. This laboratory has provided and will continue to provide opportunities to diverse students including underrepresented groups such as minorities. Lab personnel will actively participate in disseminating research results, and research findings will be disseminated broadly and in a timely manner. Genetic resources will be made available to the research community through a freely available sequence repository shortly after acquisition.

该奖项是根据2009年《美国复苏与再投资法》（公法111-5）资助的。 动物的替代失去身体部位的能力差异很大。 虽然某些动物（例如人类）无法重新生长大多数身体部位，而另一些则可以从原始动物的小碎片中重新生长整个身体。 这项研究的最终目标是了解这种变异的根本原因，并确定可能导致再生，身体部位置换过程，失败或进行的因素。 具体而言，这项工作集中于两个紧密相关的分段蠕虫物种，其中一项可以再生其头部，而另一个则不能这样做，除非切割发生在发育中非常年轻的组织内。 这两个物种中的研究将识别基因和发育过程，即使通常不能这样做，也可能会使动物再生。确定可以在原本非再生物种中引起再生的特定条件，将进一步了解成功再生的自然块，并提出规避这些块的途径。这项工作将促进对多元化的本科，研究生和研究生研究人员在一个高度支持强大指导的环境中的培训。该实验室已经提供并将继续为包括代表性不足的少数群体等不同学生提供机会。实验室人员将积极参与分发研究结果，研究结果将被广泛，及时地传播。 收购后不久，将通过免费可用的序列存储库来提供遗传资源。