Collaborative Research: Tribologically Durable UHMWPE Nanocomposites for Total Joint Replacements: Nano-mechanics and Bio-tribological Modeling

合作研究：用于全关节置换的耐摩擦 UHMWPE 纳米复合材料：纳米力学和生物摩擦学建模

• 批准号: 0856510
• 负责人: Weihong (Katie) Zhong
• 金额: --
• 依托单位: Washington State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0856510&HistoricalAwards=false
• 关键词: Collaborative; Research; Tribologically; Durable; UHMWPE

Collaborative Research: Tribologically Durable UHMWPE Nanocomposites for Total Joint Replacements: Nano-mechanics and Bio-tribological Modeling This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). The research objective of this project is to study the nano-mechanics and bio-tribology aspects of graphitic UHMWPE nanocomposites for total joint replacements, and to establish models for the design of tribologically durable materials that can provide longer life expectancy for prosthetic implants. The conventional method for increasing wear resistance of UHMWPE components of total joint replacements is crosslinking UHMWPE material by irradiation followed by re-melting. These methods have resulted in severe problems such as reduced fatigue strength and toughness, as well as the generation of wear debris in the most biologically active size range, raising concerns of osteolysis, bone resorption, and implant loosening. This project aims at solving those problems through studies of nano-mechanics and bio-tribological modeling for durable UHMWPE nanocomposites reinforced by newly developed graphitic nanomaterials. This research will result in a new design methodology for polymer materials used in artificial joints, and thus lead to optimal UHWMPE nanocomposites and dramatically extended life expectancy for total joint replacements. If successful, the results of this project will provide a base for design and development of tribologically durable UHMWPE materials that can lead to longer life spans for a variety of artificial joints to meet a wide range of patient needs. This research will benefit and contribute to bio-engineering, nanotechnology, materials science, heath care system capability, and our society at large. It will also contribute to multi-level education in both ND and WA states. This project will directly involve both undergraduate and graduate students, and will also lead to new lectures for course development in both universities. Native American tribal college students, woman and minority students will benefit from this research through summer workshops

协作研究：摩擦学耐用的UHMWPE纳米复合材料用于总置换：纳米力学和生物文明模型模型该奖项是根据2009年《美国复苏和再投资法》（公共法第111-5）资助的。该项目的研究目标是研究石墨UHMWPE纳米复合材料的纳米力学和生物图形学方面，以进行总关节置换，并为设计具有较长寿命的寿命为假体植入物提供寿命更长的材料建立模型。通过辐射，随后重新融化，可以增加关节置换量的UHMWPE组件的耐磨性的常规方法是交联的UHMWPE材料。这些方法导致了严重的问题，例如疲劳强度和韧性降低，以及在最活跃的尺寸范围内产生的磨损碎片，引起了骨溶解，骨吸收和植入物松弛的关注。该项目旨在通过研究新开发的石墨纳米材料加强的耐用UHMWPE纳米复合材料来解决纳米力学和生物文献建模。这项研究将为人造关节中使用的聚合物材料提供一种新的设计方法，从而导致最佳的UHWMPE纳米复合材料，并极大地延长了总关节置换率的预期寿命。如果成功的话，该项目的结果将为设计和开发摩擦学耐用的UHMWPE材料提供基础，这些材料可能会导致寿命更长的寿命，以满足各种人造关节，以满足广泛的患者需求。这项研究将受益并有助于生物工程，纳米技术，材料科学，健康护理系统能力以及我们的整个社会。它还将在ND和WA州促进多层教育。该项目将直接涉及本科生和研究生，还将为两所大学的课程发展提供新的讲座。美洲原住民学院的学生，女学生和少数民族学生将通过夏季研讨会从这项研究中受益