Arabidopsis 2010 Collaborative Research: RUI: Quantifying mutation parameters in a fitness landscape: Spontaneous mutation in A. thaliana in its native range.
拟南芥 2010 合作研究:RUI:量化适应度景观中的突变参数:拟南芥在其原生范围内的自发突变。
基本信息
- 批准号:0845413
- 负责人:
- 金额:$ 25.84万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-01 至 2015-09-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Mutations are errors in replication that result in offspring having a different gene than either parent. They play a fundamental role in many biological phenomena; they are the ultimate source of all genetic variation and are manifested as the rich diversity of life on earth. Mutations are also the source of genetically based diseases of humans and other organisms. Despite the biological importance of mutations, little is known of their fundamental properties, including their rate of production and their effects on the health of the organism. The goal of this project is to estimate mutation rates and to quantify the effects of mutations on the survivorship and reproduction of individuals. These characteristics will be estimated by allowing mutations to accumulate in the offspring of a number of homozygous parents, using the plant Arabidopsis thaliana. Any genetic differences in the offspring must be due to new mutations. The effects of these mutations will be quantified at field sites where parental plants were originally collected. The rate and fitness effects of mutations will be determined in the field, where they would actually occur, providing a more realistic estimate than is possible in controlled laboratory conditions.This research significantly advances the fundamental understanding of mutation effects, and has broad implications for a range of biological questions from understanding the origin of heritable diseases to the role of mutations in the fate of small populations. Because the study organism, Arabidopsis thaliana, is a widely used model organism, these new mutation resources will become a valuable resource for the community of researchers studying this species or its close relatives. Students from under-represented groups will be recruited to participate in the research, and the investigators plan to develop new student labs in ecology and genetics at the high school and undergraduate levels.
突变是复制过程中的错误,导致后代具有与亲本不同的基因。它们在许多生物现象中发挥着重要作用。它们是所有遗传变异的最终根源,并表现为地球上生命的丰富多样性。突变也是人类和其他生物体遗传疾病的根源。尽管突变具有生物学重要性,但人们对它们的基本特性知之甚少,包括它们的产生率及其对生物体健康的影响。该项目的目标是估计突变率并量化突变对个体生存和繁殖的影响。这些特征将通过使用植物拟南芥在许多纯合亲本的后代中累积突变来估计。后代的任何遗传差异必定是由于新的突变造成的。这些突变的影响将在最初收集亲本植物的田间地点进行量化。突变的发生率和适应度效应将在实际发生的现场确定,从而提供比受控实验室条件下更现实的估计。这项研究极大地推进了对突变效应的基本理解,并对突变效应具有广泛的影响。一系列生物学问题,从了解遗传性疾病的起源到突变在小群体命运中的作用。由于研究生物拟南芥是一种广泛使用的模式生物,这些新的突变资源将成为研究该物种或其近亲的研究人员群体的宝贵资源。来自代表性不足群体的学生将被招募参与这项研究,研究人员计划在高中和本科阶段建立新的生态学和遗传学学生实验室。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Matthew Rutter其他文献
Matthew Rutter的其他文献
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{{ truncateString('Matthew Rutter', 18)}}的其他基金
RUI: Collaborative: unPAK: undergraduates Phenotyping Arabidopsis Knockouts: A distributed genomic approach to examine evolutionarily important traits
RUI:协作:unPAK:本科生拟南芥表型敲除:检查进化重要性状的分布式基因组方法
- 批准号:
1355106 - 财政年份:2014
- 资助金额:
$ 25.84万 - 项目类别:
Continuing Grant
Collaborative: RUI: The natural history of mutations: sequence and fitness data from Arabidopsis thaliana mutation accumulation lines
合作:RUI:突变的自然历史:来自拟南芥突变积累系的序列和适应度数据
- 批准号:
1258053 - 财政年份:2013
- 资助金额:
$ 25.84万 - 项目类别:
Standard Grant
Collaborative: RUI: Engaging undergraduates in genomic questions and environmental context: building a database of complex phenotypes for plant knockout mutants
合作:RUI:让本科生参与基因组问题和环境背景:为植物敲除突变体建立复杂表型数据库
- 批准号:
1052262 - 财政年份:2011
- 资助金额:
$ 25.84万 - 项目类别:
Standard Grant
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1021463 - 财政年份:2010
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