Control of speech and nonspeech respiratory, phonatory and oral movements: clinical studies

言语和非言语呼吸、发声和口腔运动的控制：临床研究

基本信息

批准号：
190067084
负责人：
Professor Dr. Wolfram Ziegler
金额：
--
依托单位：
Institut für Phonetik und Sprachverarbeitung
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2011
资助国家：
德国
起止时间：
2010-12-31 至 2017-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/190067084?language=en
关键词：
Control speech nonspeech respiratory phonatory

项目摘要

The proposed project is an extension of our current study of the neural and functional organisation of speech movements. During the first research period of the project we were able to collect a data set that is exceptional for its sample size, its high standard of investigation procedures as well as the comprehensiveness of the analysed features. These data allow for a thorough description of the voluntary skills of the motor speech apparatus under different speech and non-speech task conditions, both in neurologically healthy adults of all ages (N > 120) and in individuals with neurological movement disorders (N > 100).The extension project proposed here comprises three studies that pursue the following objectives:(i) Using advanced statistical analyses we aim to investigate the factorial structures of the speech and non-speech tasks and to validate the (speech and non-speech) factors for their predictive value regarding the communicative variables intelligibility, naturalness and (temporal) efficiency. The results of these analyses will enable us to implement classificatory procedures for the automatic acoustic detection of a dysarthric disorder and specific dysarthric features, respectively. (Study 1)(ii) As patients with primary dystonia and Deep Brain Stimulation (DBS) of the Globus pallidus internus (GPi) were included in the first research period, we are now afforded the opportunity to extend our research paradigm to a constellation, which is of particular interest from a neurophysiological perspective. In comparing Stim-ON and Stim-OFF conditions we will be able to test a hypothesis currently discussed, according to which well-learned, automatic and new, non-habitual motor sequences involve different basal ganglia control circuits. (Study 2)(iii) We will finally expand our core research question to address a further, theoretically and clinically interesting case: we will test the hypothesis that the production of single (isolated) speech sounds relies on non-speech motor control mechanisms and therefore corresponds to the requirement profiles of non-speech tasks. The results of this experiment will have important implications both for our theoretical understanding of speech sounds as core units in speech production and for the well-established clinical practice to use single speech sounds in the assessment and treatment of speech sound disorders (apraxia of speech, phonological output disorders in aphasia). (Study 3).

拟议的项目是我们当前对语音运动神经和功能组织的研究的扩展。在项目的第一个研究期间，我们能够收集一个针对其样本量，其高标准调查程序以及分析特征的全面性的数据集。这些数据允许在不同年龄的神经健康的成年人（n> 120）和神经运动障碍的个体（n> 100）（n> 100 ）。此处提出的扩展项目包括三项追求以下目标的研究：（i）使用高级统计分析，我们旨在调查语音和非语音任务的阶乘结构，并验证（语音和非语音）因素因为它们关于交流变量的预测价值可理解，自然性和（时间）效率。这些分析的结果将使我们能够分别实施分类违反障碍和特定质心特征的分类程序。（研究1）（ii）作为原发性肌张力障碍的患者和Globus pallidus Interus（GPI）的深脑刺激（DBS）的患者，在第一个研究期内，我们现在有机会将我们的研究范式扩展到一个体系，从神经生理学的角度来看，这尤其令人感兴趣。在比较刺激和刺激条件时，我们将能够检验当前讨论的假设，根据该假设，该假设良好，自动和新的，非海博的运动序列涉及不同的基底神经节控制电路。（研究2）（iii）我们最终将扩大我们的核心研究问题，以解决理论上和临床上有趣的案例：我们将测试以下假设：单个（孤立）语音的产生依赖于非语音运动控制机制和因此，对应于非语音任务的要求。该实验的结果将对我们对语音作为语音生产的核心单位的理论理解以及良好的临床实践具有重要意义失语症中的语音输出障碍）。（研究3）。