Green Catalysis

绿色催化

• 批准号: 0809901
• 负责人: L. Keith Woo
• 金额: --
• 依托单位: Iowa State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0809901&HistoricalAwards=false
• 关键词: Green; Catalysis

This award by the Inorganic, Bioinorganic, and Organometallic Chemistry Program supports Professor L. Keith Woo at Iowa State University for the development of environmentally-friendly, sustainable approaches to catalytic processes and technologies. Biological systems provide the inspiration and insight into the "green" catalyst design employed by the Woo research group. The first project is based on the central role of iron porphyrins (heme) as the active sites in a variety of vital enzymes such as cytochrome P-450 and peroxidases. A diverse group of postdoctoral, graduate, and undergraduate students will investigate new catalytic applications of these versatile compounds. The second project will accelerate the development, optimization, and production of effective catalysts using molecular iterations. This strategy provides a large random library of single-stranded DNA (ssDNA) oligomers which can act as water-soluble catalysts for organic reactions. By involving a massive collection of different DNA molecules in an inherently selective and high-throughput process, maximal structural and compositional diversity can be rapidly screened. Such screening can dramatically reduce the time for catalyst identification and development. Combinatorial approaches such as these have made great impacts on drug design, but its use in transition metal catalyst design is in its infancy. These research projects foster teamwork and cooperation among Professor Woo's students at Iowa State University and exemplifies interdisciplinary collaboration with chemists, biochemists, biologists, and engineers.

无机，生物无机和有机金属化学计划的奖项支持爱荷华州立大学的L. Keith Woo教授，开发环保，可持续的催化过程和技术。 生物系统为Woo研究小组采用的“绿色”催化剂设计提供了灵感和洞察力。 第一个项目基于铁卟啉（血红素）作为多种重要酶（例如细胞色素p-450和过氧化物酶）中的活性位点的核心作用。 多样化的博士后，毕业生和本科生将研究这些多功能化合物的新催化应用。 第二个项目将使用分子迭代加速有效催化剂的开发，优化和生产。 该策略提供了单链DNA（SSDNA）低聚物的大型随机文库，该曲线可以充当有机反应的水溶性催化剂。 通过在固有的选择性和高通量过程中涉及大量不同DNA分子的集合，可以快速筛选最大的结构和组成多样性。 这种筛查可以大大减少催化剂识别和发育的时间。 诸如此类的组合方法对药物设计产生了很大的影响，但是它在过渡金属催化剂设计中的使用仍处于起步阶段。 这些研究项目促进了爱荷华州立大学Woo教授的学生之间的团队合作和合作，并体现了与化学家，生物化学家，生物学家和工程师的跨学科合作。