NSF Minority Postdoctoral Research Fellowship for FY2008

2008 财年 NSF 少数族裔博士后研究奖学金

• 批准号: 0805691
• 负责人: Charles Stewart
• 金额: $ 12.3万
• 依托单位: Stewart Charles E
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0805691&HistoricalAwards=false
• 关键词: NSF; Minority; Postdoctoral; Research; Fellowship

This action funds an NSF Minority Postdoctoral Research Fellowship for FY 2008. The fellowship supports a research and training plan in a host laboratory for the Fellow who also presents a plan to broaden participation in biology. The title of the research and training plan for this fellowship to Charles E. Stewart is "Structural basis for the evolution of novel functions in type III polyketide synthases" The host institution for this research is the Salk Institute and the sponsoring scientist is Dr. Joseph Noel.Polyketide synthases are enzymes that produce an amazing array of natural products in plants and bacteria that find important uses in medicine and agriculture. The diversity of these compounds is related to the variety of cyclization mechanisms used by the enzymes during biosynthesis. This research investigates the structural changes in polyketide synthases that show different functions and result in different products. The 3-dimensional structure of two closely related polyketide synthases with different cyclization patterns are being studied using x-ray crystallography. Comparison of these structures will help identify the specific amino acids responsible for the different cyclization patterns. The training objectives are to gain skills in enzymology and structural biology, especially as they relate to natural products, scientific ethics and science communication. The broader impacts include increasing the number of minorities through innovative outreach programs targeting students of various ages and education from the junior high to the post-doctoral level. This research will have broad impacts across academic disciplines, in particular the fields of biology, chemical biology, and natural product chemistry.

这项行动为2008财年的NSF少数族裔研究奖学金提供了资金。该奖学金支持该研究员的主机实验室的研究和培训计划，该研究员还提出了扩大生物学参与计划的计划。这项奖学金的研究和培训计划的标题是“ Charles E. Stewart是“在III型Polyketide合酶中发展新功能的结构性基础”这项研究的宿主机构是Salk Institute，并且赞助科学家是Joseph Noel.- Polypolketide博士。PolyketideSynthanses是生产植物和细菌中出色的酶的酶。这些化合物的多样性与生物合成过程中酶使用的各种环化机制有关。 这项研究调查了聚酮化合物合成酶的结构变化，这些变化显示出不同的功能并导致不同的产物。使用X射线晶体学研究了两种具有不同环化模式的密切相关的聚酮化合物合成酶的3维结构。这些结构的比较将有助于确定负责不同环化模式的特定氨基酸。培训目标是获得酶学和结构生物学的技能，尤其是与天然产品，科学伦理和科学交流有关的技能。更广泛的影响包括通过针对各个年龄和教育的学生从初中到博士后水平来增加少数民族的数量。这项研究将在学科中产生广泛的影响，尤其是生物学，化学生物学和自然产品化学领域。