Asymmetric Radical Addition Reactions

不对称自由基加成反应

• 批准号: 0749850
• 负责人: Gregory Friestad
• 金额: $ 39万
• 依托单位: University of Iowa
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0749850&HistoricalAwards=false
• 关键词: Asymmetric; Radical; Addition; Reactions

With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Gregory K. Friestad of the Chemistry Department at the University of Iowa. The project focuses on the development of new stereoselective methods to achieve asymmetric amine synthesis via free radical addition reactions. In particular, these studies will expand the scope and improve the efficiency of Mn-mediated radical additions, provide new methods for the construction of quaternary carbon stereocenters, and investigate asymmetric catalysis of radical additions to C=N bonds. A new radical addition approach to chiral amines, involving addition to the C=C bond of chiral enamides with subsequent stereoselective trapping by tandem bond constructions, will be studied. This project will contribute to knowledge of the chemistry of radical addition reactions that generate chiral amines. Since chiral amines play crucial roles in pharmaceutical chemistry, these investigations are expected to have broad impact on research in the health sciences. This project will also provide important undergraduate, graduate and postdoctoral training in preparation for careers in health sciences research.

有机和高分子化学项目通过该奖项来支持爱荷华大学化学系 Gregory K. Friedad 教授的研究。 该项目重点开发新的立体选择性方法，通过自由基加成反应实现不对称胺合成。 特别是，这些研究将扩大Mn介导的自由基加成的范围并提高效率，为季碳立构中心的构建提供新方法，并研究C=N键自由基加成的不对称催化。 将研究一种新的手性胺自由基加成方法，包括加成手性烯酰胺的 C=C 键，随后通过串联键结构进行立体选择性捕获。该项目将有助于了解产生手性胺的自由基加成反应的化学知识。 由于手性胺在药物化学中发挥着至关重要的作用，因此这些研究预计将对健康科学研究产生广泛影响。 该项目还将提供重要的本科生、研究生和博士后培训，为健康科学研究职业做好准备。