Collaborative Research: Molecular Adaptation and Gametic Competition

合作研究：分子适应和配子竞争

基本信息

批准号：
0743125
负责人：
Andrew Clark
金额：
$ 8.15万
依托单位：
Cornell University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2008
资助国家：
美国
起止时间：
2008-08-01 至 2012-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0743125&HistoricalAwards=false
关键词：
Collaborative Research Molecular Adaptation Gametic

项目摘要

Extensive laboratory research indicates that a relatively small number of male and female reproductive proteins play key roles in determining differential success of gametes. These molecules are regulating complex communications in what may be antagonistic interactions between male and female reproductive interests. Little is known about the molecular basis for these interactions and their relative importance in the wild. This study will identify the genetic basis for male-male and male-female interactions, determine how associations between genotype and phenotype vary when the male competitor?s genotype varies, and directly identify which male reproductive genes mediate male x male interactions. This study also will investigate how mating status varies across the day, the season, densities and as a function of the female genotype and allow the most direct tests possible of the relationship between genotypic and phenotypic variation in nature.Among its broader impacts, this study will inspired a diverse collection of undergraduates through direct participation in research projects by engaging them in honors projects, giving them opportunities to present results at international meetings, and motivating them to pursue careers in scientific research. This study also will produce shared infrastructure, including a large number of Drosophila cultures that are openly available, and a publicly available Bayesian estimator for association testing using brood-structured data.

广泛的实验室研究表明，相对较少的男性和女性生殖蛋白在确定配子的差异成功方面起着关键作用。这些分子正在调节男性和女性生殖兴趣之间的拮抗相互作用中的复杂通信。关于这些相互作用的分子基础及其在野外的相对重要性知之甚少。这项研究将确定男性和男性相互作用的遗传基础，确定何时基因型和表型之间的关联在雄性竞争者的基因型变化时如何变化，并直接识别哪些雄性生殖基因介导男性X男性相互作用。 This study also will investigate how mating status varies across the day, the season, densities and as a function of the female genotype and allow the most direct tests possible of the relationship between genotypic and phenotypic variation in nature.Among its broader impacts, this study will inspired a diverse collection of undergraduates through direct participation in research projects by engaging them in honors projects, giving them opportunities to present results at international meetings, and motivating them to pursue careers in科学研究。这项研究还将产生共享的基础设施，包括公开可用的大量果蝇培养物，以及使用育雏结构数据进行关联的公开贝叶斯估计量。