Collaborative Research: Electrofluidic Carbon Nanofiber Arrays for Multi-Dimensional Separations

合作研究：用于多维分离的电流体碳纳米纤维阵列

• 批准号: 0729250
• 负责人: Jason Heikenfeld
• 金额: $ 11.35万
• 依托单位: University of Cincinnati Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0729250&HistoricalAwards=false
• 关键词: Collaborative; Research; Electrofluidic; Carbon; Nanofiber

PROPOSAL NUMBER: 0729250 / 0728860PRINCIPAL INVESTIGATOR: Jason Heikenfeld / Philip RackINSTITUTION: University of Cincinnati / University of Tennessee - KnoxvillePROPOSAL TITLE: Collaborative Research: Electrofluidic Carbon Nanofiber Arrays for Multi-Dimensional SeparationsThe objective of this collaborative proposal is to create a novel multiphase transport platform that provides new capabilities for multidimensional separations. The team will construct two-dimensional arrays of containment cells, each cell consisting of 10,000 closely spaced (10's-100's nm) electrofluidic carbon nanofibers (ECNFs). These vertically oriented ECNFs include a highly conformal hydrophobic dielectric coating. Cells of ~250x250-micrometer perimeter are electrically controlled by an underlying thin film transistor. The entire array is top-sealed and forms a ~10-micrometer high microfluidic channel. This creates a 2D array of highly active cells that can rapidly pump an aqueous phase and one or more immiscible phases. This approach is unique since all separation mechanisms are simultaneously active and switchable in each cell. Specific research aims include: (1) investigate 3-dimensional control of passive transport through a linear array of ECNF cells; (2) activate multiphase oil/water/particle pumping via integration with a thin-film Si transistor array; (3) validate that the platform can perform high-value separations in the dimensions of x-y location, size, mass, surface energy, and ionic charge. Leading scientific issues include: (a) providing the first knowledge of the tradeoff between dimensionality and peak capacity in a truly integrated system; (b) providing a new mechanism for understanding particle and multi-phase fluid flow at Debye (nano) scales; (c) making critical first steps towards highly active nanostructures that can mimic intracellular vesicle trafficking and active membrane transport. This project will directly impact the fields of drug discovery, lab-scale separations, human-onchip sensors, and nanotechnology. The team has expertise in several areas: drug-discovery (NeoCytex Biopharma), membrane separations (NSF Center for Membrane Applied Science and Technology), and nanotechnology development (Luna Nanoworks Division). The team has already utilized their preliminary research in order to scientifically engage two groups of K-8 students. The team will continue to focus on critically important stimulation of minorities at the K-8 level and will broaden educational aims to include a unique undergraduate research exchange between Cincinnati and Tennessee.

提案编号：0729250 / 0728860主要研究员：Jason Heikenfeld / Philip Rack机构：辛辛那提大学/田纳西大学 - 诺克斯维尔提案标题：合作研究：用于多维分离的电流体碳纳米纤维阵列该合作提案的目标是创建一个新颖的多相传输平台这提供了新的能力多维分离。该团队将构建二维密封单元阵列，每个单元由 10,000 个紧密间隔（10 至 100 纳米）的电流体碳纳米纤维 (ECNF) 组成。这些垂直定向的 ECNF 包括高度保形的疏水介电涂层。周长约为 250x250 微米的单元由底层薄膜晶体管进行电控制。整个阵列是顶部密封的，形成约 10 微米高的微流体通道。这创建了高活性细胞的二维阵列，可以快速泵送水相和一个或多个不混溶相。这种方法是独特的，因为所有分离机制在每个单元中同时激活和切换。具体研究目标包括：（1）研究通过 ECNF 细胞线性阵列被动运输的 3 维控制； (2) 通过与薄膜硅晶体管阵列集成激活多相油/水/颗粒泵送； (3)验证该平台可以在x-y位置、尺寸、质量、表面能和离子电荷维度上进行高价值分离。主要科学问题包括：(a) 提供真正集成系统中维数和峰值容量之间权衡的第一手知识； (b) 提供一种新的机制来理解德拜（纳米）尺度的粒子和多相流体流动； （c）朝着可以模拟细胞内囊泡运输和活性膜运输的高活性纳米结构迈出关键的第一步。该项目将直接影响药物发现、实验室规模分离、人体芯片传感器和纳米技术领域。该团队在多个领域拥有专业知识：药物发现（NeoCytex Biopharma）、膜分离（NSF 膜应用科学与技术中心）和纳米技术开发（Luna Nanoworks 部门）。该团队已经利用他们的初步研究来科学地吸引两组 K-8 学生。该团队将继续关注对 K-8 级别的少数族裔至关重要的刺激，并将扩大教育目标，包括辛辛那提和田纳西州之间独特的本科生研究交流。