Der Einfluss von kognitiven Inhibitionsmechanismen auf die Rückfallwahrscheinlichkeit alkoholabhängiger Patienten

认知抑制机制对酒精依赖患者复发概率的影响

• 批准号: 183521785
• 负责人: Professor Dr. Thomas Beblo
• 金额: --
• 依托单位: Klinik für Psychiatrie und Psychotherapie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/183521785?language=en
• 关键词: Der; Einfluss; von; kognitiven; Inhibitionsmechanismen

The advantages of laser surgery can be diminished by the lack of haptic feedback during the ablation of tissue. A surgeon receives no information about the exact laser beam penetration depth or type of the ablated tissue at the bottom of the cut, risking to induce iatrogenic damage or destruction of anatomical structures like major nerves. Due to that the application of laser surgery is limited to superficial structures so far. To establish laser sugery as an universally applicable tool it is necessary to develp a tissue specific controlled surgical laser. It is the aim of this interdisciplinary research project to develp a sensorbased tissue specific feedback system to automatically control laser ablation in the surgical field. The research project sets a special focus on nerve preservation by remote optical tissue discrimination. Two surgical procedures are chosen for the experiments which typically inherit a high risk of iatrogenic nerve damage: the osteotomy of the mandible in the vicinity of the inferior alveolar nerve and the surgery of the parotid gland in the vicinity of the facial nerve. The tissue discrimination is conducted by diffuse reflectance and auto-fluorescence spectroscopy combined with optical process emissions caused by Er:YAG laser tissue ablation to provide a constant feedback mechanism during laser processing. After assessment of the experimental data, a proof-of-principle ablation sensor and feedback control system will be established and further validated on in vivo animal studies.

组织消融过程中缺乏触觉反馈可能会削弱激光手术的优势。外科医生无法收到有关激光束准确穿透深度或切口底部消融组织类型的信息，因此存在引起医源性损伤或主要神经等解剖结构破坏的风险。由于目前激光手术的应用仅限于浅表结构。为了使激光手术成为一种普遍适用的工具，有必要开发一种组织特异性受控手术激光器。这个跨学科研究项目的目的是开发一种基于传感器的组织特定反馈系统，以自动控制外科领域的激光消融。该研究项目特别关注通过远程光学组织辨别来保存神经。实验选择了两种通常具有高医源性神经损伤风险的外科手术：下牙槽神经附近的下颌骨截骨术和面神经附近的腮腺手术。组织区分是通过漫反射和自体荧光光谱结合 Er:YAG 激光组织烧蚀引起的光学过程发射来进行的，以在激光加工过程中提供恒定的反馈机制。在评估实验数据后，将建立原理验证消融传感器和反馈控制系统，并在体内动物研究中进一步验证。