NER: "Repair and Go" with Nanoparticle-filled Polymer Capsules

NER：使用纳米粒子填充聚合物胶囊“修复并运行”

• 批准号: 0707420
• 负责人: Anna Balazs
• 金额: --
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0707420&HistoricalAwards=false
• 关键词: NER; Repair; Go; Nanoparticle; filled

Anna C. Balazs 0707420Intellectual MeritNew types of nanoparticles, which display a large range of novel compositions and structures are now being generated at a distinctly rapid pace. These particles may have a wide variety of desirable properties, from novel electromagnetic behavior and mechanical reinforcement in soft materials, to flavor, fragrance and color in consumer goods and food. It remains, however, a critical challenge to establish a common method for incorporating this variety of nanoparticles into a range of materials. The encapsulation of nanoparticles into microcapsules -- which encompass a fluid-filled core and polymeric shell -- offers a key solution to this challenge; the microcapsules provide an effective means of regulating the release rate of the enclosed nanoparticles and targeting the delivery of the particles onto surfaces. The latter attribute is especially important for a number of applications. For example, for the nanoparticles to be effective in cosmetics and personal care products, they must reach the skin or hair; in a similar manner, for printing, textile and coating applications, the particles must be targeted to a substrate.This Nanoscale Exploratory Research project is a proof-of-concept study in nanoscience, aimed at addressing the essential needs described above. The PIs will design fluid-driven microcapsules that carry nanoparticles to a desired surface, then release the particles to provide a coating on the underlying substrate. Such "road paving" systems not only play a valuable role in the applications noted above, but also form a useful tool for micro- and nanofabrication. They will also isolate conditions where nanoparticles released from the capsules can repair the damage in an underlying substrate, and thereby establish guidelines for designing nanoparticle-filled microcapsules that perform a "repair and go" function.The project will integrate the different areas of expertise of the PIs. Balazs, the lead PI, will provide the theoretical basis to understand the dynamic behavior of nanoparticle-filled capsules, including their interactions with surfaces, and their release of nanoparticles. Emrick and Russell will provide synthesis and characterization, using amphiphilic graft copolymers as self-assembling encapsulants for nanoparticles such as quantum dots, and patterned substrates over which the capsules traverse and release their contents. By combining their efforts, the PIs plan to establish, within the one-year timeframe of the NER project, a new approach to microencapsulation and delivery of nanoparticles. On a fundamental level, the results will have intellectual merit and scientific impact since the findings will provide insight into the dynamics of multiphase assemblies in fluid environments. These results will also yield new information on how to manipulate the inherent interactions within the system (e.g., the nanoparticle-capsule, the nanoparticle-surface, and the nanoparticle-fluid interactions) to yield the desired behavior. Broad ImpactThe findings will also have a broader impact; predicting how diverse particles can be delivered controllably to a substrate within a material will allow researchers to harness the unique functionalities offered by the nanoparticles in a range of applications and technologies, including the functionalities offered by the nanoparticles in a range of applications and technologies, including the personal care, pharmaceutical and food industries. During the course of the funding period, the PIs will host a one-day symposium at the University of Massachusetts, on the topic of encapsulation and nanomaterials that are relevant to both commercial products and state-of-the-art research. The symposium, simply titled "Nanoencapsulation", will feature presentations by the PIs and other researchers from academia, as well as scientists working in corporations with products that hinge on encapsulation techniques. This meeting will have an educational impact on the students and researchers in the community and other attendees of the meeting. The project will also have an educational benefit for the young researchers working on the project. In particular, it will allow the students working on the project (one at the University of Pittsburgh and one at UMass Amherst) to see first-hand the potential benefits of integrating theoretical and experimental research into a cohesive plan of action.

Anna C. Balazs 0707420智力优点 新型纳米颗粒具有大量新颖的成分和结构，现在正在以极快的速度产生。 这些颗粒可能具有多种所需的特性，从软材料中的新颖电磁行为和机械增强，到消费品和食品中的风味、香味和颜色。 然而，建立一种将各种纳米颗粒纳入一系列材料的通用方法仍然是一个严峻的挑战。 将纳米颗粒封装到微胶囊中——它包含一个充满液体的核心和聚合物外壳——为这一挑战提供了关键的解决方案；微胶囊提供了一种有效的方法来调节所封装的纳米颗粒的释放速率并将颗粒递送到表面上。 后一个属性对于许多应用程序尤其重要。 例如，为了让纳米颗粒在化妆品和个人护理产品中发挥作用，它们必须到达皮肤或头发；以类似的方式，对于印刷、纺织和涂层应用，颗粒必须针对基材。该纳米探索性研究项目是纳米科学领域的一项概念验证研究，旨在解决上述基本需求。 PI 将设计流体驱动的微胶囊，将纳米颗粒携带到所需的表面，然后释放颗粒以在下面的基材上提供涂层。 这种“铺路”系统不仅在上述应用中发挥着宝贵的作用，而且还形成了微米和纳米制造的有用工具。 他们还将隔离从胶囊中释放的纳米颗粒可以修复底层基质损伤的条件，从而为设计具有“修复和运行”功能的纳米颗粒填充微胶囊制定指南。该项目将整合不同领域的专业知识PI。 主要 PI Balazs 将为理解纳米颗粒填充胶囊的动态行为提供理论​​基础，包括它们与表面的相互作用以及纳米颗粒的释放。 Emrick 和 Russell 将提供合成和表征，使用两亲性接枝共聚物作为纳米粒子（如量子点）的自组装封装剂，以及胶囊穿过并释放其内容物的图案化基底。 通过共同努力，PI 计划在 NER 项目的一年时间内建立一种纳米粒子微胶囊化和递送的新方法。从根本上讲，这些结果将具有智力价值和科学影响，因为这些发现将提供对流体环境中多相组件动力学的深入了解。 这些结果还将产生有关如何操纵系统内固有相互作用（例如纳米颗粒-胶囊、纳米颗粒-表面和纳米颗粒-流体相互作用）以产生所需行为的新信息。 广泛的影响研究结果还将产生更广泛的影响；预测如何将不同的颗粒可控地传递到材料内的基底上将使研究人员能够利用纳米颗粒在一系列应用和技术中提供的独特功能，包括纳米颗粒在一系列应用和技术中提供的功能，包括个人护理、制药和食品行业。在资助期间，PI 将在马萨诸塞大学举办为期一天的研讨会，主题是与商业产品和最先进研究相关的封装和纳米材料。 此次研讨会的主题为“纳米封装”，主要由 PI 和其他学术界研究人员以及在企业中从事依赖于封装技术的产品的科学家进行演讲。 这次会议将对社区的学生和研究人员以及会议的其他与会者产生教育影响。该项目还将为从事该项目的年轻研究人员带来教育效益。特别是，它将让参与该项目的学生（一名来自匹兹堡大学，一名来自麻省大学阿默斯特分校）亲眼目睹将理论和实验研究整合到一个有凝聚力的行动计划中的潜在好处。