Polarization Dependent Nonlinear Optical Properties of Biomolecules

生物分子的偏振相关非线性光学性质

• 批准号: 0640549
• 负责人: Garth Simpson
• 金额: $ 44万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-15 至 2011-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0640549&HistoricalAwards=false
• 关键词: Polarization; Dependent; Nonlinear; Optical; Properties

Garth Simpson of Purdue University is supported by the Experimental Physical Chemistry Program to develop a systematic framework that will provide a foundation for interpreting polarization-dependent nonlinear optical (NLO) measurements of oriented biomolecular assemblies. The primary objectives are to: (1) refine and test computational methods based on perturbation theory for describing the polarization-dependent NLO properties of biopolymers, (2) develop new instrumental methods for detailed polarization analysis in second harmonic generation (SHG), sum frequency generation (SFG), and two-photon absorption, and (3) assess the range of validity of the perturbation theory approach from combined electronic SHG, vibrational SFG, and electronic two-photon absorption measurements of model oriented bacteriorhodopsin thin films and collagen fibrils. Nonlinear optical methods have great promise as probes to understand microscopic structure in biological systems. This project will enable significant development of new techniques that can be used effectively in chemistry and biology. The useful impacts of this work will be extended to the broader community with the continued development of the freely distributed software package NLOPredict, and initiation and organization of a new annual summer meeting on nonlinear optics.

普渡大学的加思·辛普森 (Garth Simpson) 在实验物理化学计划的支持下开发了一个系统框架，该框架将为解释定向生物分子组装体的偏振相关非线性光学 (NLO) 测量奠定基础。 主要目标是：(1) 改进和测试基于微扰理论的计算方法，用于描述生物聚合物的偏振相关 NLO 特性，(2) 开发新的仪器方法，用于二次谐波发生 (SHG)、和频率中详细的偏振分析产生（SFG）和双光子吸收，以及（3）通过组合电子 SHG、振动 SFG 和面向模型的电子双光子吸收测量来评估微扰理论方法的有效性范围细菌视紫红质薄膜和胶原纤维。非线性光学方法作为了解生物系统微观结构的探针具有广阔的前景。该项目将促进可有效用于化学和生物学的新技术的重大发展。 随着免费分发软件包 NLOPredict 的持续开发，以及新的非线性光学年度夏季会议的发起和组织，这项工作的有益影响将扩展到更广泛的社区。