Polarization Dependent Nonlinear Optical Properties of Biomolecules

生物分子的偏振相关非线性光学性质

• 批准号: 0640549
• 负责人: Garth Simpson
• 金额: $ 44万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-15 至 2011-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0640549&HistoricalAwards=false
• 关键词: Polarization; Dependent; Nonlinear; Optical; Properties

Garth Simpson of Purdue University is supported by the Experimental Physical Chemistry Program to develop a systematic framework that will provide a foundation for interpreting polarization-dependent nonlinear optical (NLO) measurements of oriented biomolecular assemblies. The primary objectives are to: (1) refine and test computational methods based on perturbation theory for describing the polarization-dependent NLO properties of biopolymers, (2) develop new instrumental methods for detailed polarization analysis in second harmonic generation (SHG), sum frequency generation (SFG), and two-photon absorption, and (3) assess the range of validity of the perturbation theory approach from combined electronic SHG, vibrational SFG, and electronic two-photon absorption measurements of model oriented bacteriorhodopsin thin films and collagen fibrils. Nonlinear optical methods have great promise as probes to understand microscopic structure in biological systems. This project will enable significant development of new techniques that can be used effectively in chemistry and biology. The useful impacts of this work will be extended to the broader community with the continued development of the freely distributed software package NLOPredict, and initiation and organization of a new annual summer meeting on nonlinear optics.

普渡大学的加思·辛普森（Garth Simpson）得到了实验物理化学计划的支持，以开发系统的框架，该框架将为解释依赖于极化的非线性光学（NLO）测量的基础。 主要目的是：（1）基于扰动理论的完善和测试计算方法，以描述生物聚合物的极化依赖性NLO特性，（2）开发新的工具方法，用于第二次谐波生成（SHG），总和频率产生（SHG），总和频率产生（SFG）和两光频率范围的详细极化分析（SHG）和（3）的组合范围（3）。 SFG和电子二光子吸收测量，以模型为导向的细菌蛋白薄膜和胶原蛋白原纤维。非线性光学方法具有巨大的希望，因为探针可以理解生物系统中的微观结构。该项目将使可以在化学和生物学中有效使用的新技术的重大开发。 这项工作的有用影响将扩展到更广泛的社区，并持续开发自由分发的软件包Nlopredict，以及Nonlinear Optics的新年度夏季会议的启动和组织。