CAREER: Ultrasensitive optical spectroscopy at a single particle level

职业：单粒子水平的超灵敏光谱

• 批准号: 0547475
• 负责人: Zhiwen Liu
• 金额: $ 40万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0547475&HistoricalAwards=false
• 关键词: CAREER; Ultrasensitive; optical; spectroscopy; single

Liu0547475AbstractIntellectual Merit:This CAREER program is focused on the development of a new single-particle optical spectroscopy technology using white light supercontinuum optical tweezers. The proposed supercontinuum tweezers can not only trap a particle but also perform broadband optical scattering/absorption and coherent anti-Stokes Raman scattering spectroscopy on the trapped particle, taking advantage of the broad bandwidth of the supercontinuum. Both the physical and chemical features (e.g., size, refractive index, chemical composition) of the trapped particle can therefore be probed in situ. Over the next five years, the PIs research will be focused on the following three tasks: 1) systematically investigate the properties of supercontinuum trap and calibrate the force; 2) investigate broadband optical scattering spectroscopy of a single trapped particle; and 3) investigate broadband coherent anti-Stokes Raman scattering spectroscopy of a single trapped particle.Broader Impact:The proposed research can potentially result in major advancement of the current single-particle spectroscopy and optical tweezers technologies, and is expected to have significant impact on many areas ranging from engineering and materials science to biology and biomedicine. In addition, this CAREER program will provide a great opportunity to expose students to the broad spectrum of optics and to train them through the proposed research which includes calibrating the force of supercontinuum tweezers, developing experimental techniques and systems for single particle spectroscopy, and developing simulation tools to analyze the measured spectra. Efforts will be made to foster woman and minority students to participate in the research. Education opportunities will also be provided for high school teachers and K-12 students.

Liu0547475Abstract智力优势：该职业计划的重点是使用白光超连续谱光镊开发新型单粒子光谱技术。所提出的超连续谱镊子不仅可以捕获粒子，还可以利用超连续谱的宽带宽，对捕获的粒子进行宽带光学散射/吸收和相干反斯托克斯拉曼散射光谱。因此，可以原位探测被捕获粒子的物理和化学特征（例如尺寸、折射率、化学成分）。未来五年，PI的研究将重点关注以下三项任务：1）系统研究超连续谱陷阱的性质并标定力； 2）研究单个捕获粒子的宽带光学散射光谱； 3）研究单个被捕获粒子的宽带相干反斯托克斯拉曼散射光谱。更广泛的影响：所提出的研究可能会导致当前单粒子光谱和光镊技术的重大进步，并预计将对从工程和材料科学到生物学和生物医学的许多领域。此外，该职业计划还将提供一个绝佳的机会，让学生接触广泛的光学知识，并通过拟议的研究对他们进行培训，其中包括校准超连续谱镊子的力、开发单粒子光谱学的实验技术和系统以及开发模拟分析测量光谱的工具。将努力培养女性和少数民族学生参与研究。还将为高中教师和 K-12 学生提供教育机会。