Accomplishment-Based Renewal: Hitchhiking and Molecular Evolution of the Avian Mhc

基于成就的更新：鸟类 Mhc 的搭便车和分子进化

• 批准号: 0500893
• 负责人: Scott Edwards
• 金额: --
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0500893&HistoricalAwards=false
• 关键词: Accomplishment; Based; Renewal; Hitchhiking; Molecular

This research will continue to use genomic resources known as cosmid libraries to study in detail the evolution of genes in the major histocompatibility complex (Mhc) of birds. The Mhc is a genetic locus associated with disease resistance and susceptibility in natural populations. The evolutionary processes at this locus can be compared to processes in other vertebrate groups, in particular mammals, which are comprehensively studied as part of whole genome projects. The genetic variability of loci within and outside of Mhc will also be studied in order to understand whether elevated levels of variability within Mhc is due to heterozygote advantage, as opposed levels in the non-coding, neutral regions. Finally, the extent of genetic linkage between coding and non-coding regions will be analyzed. The resources provided by cosmid libraries will permit a variety of population genetic studies in genetically less tractable songbird species. These studies will be important for understanding how a highly polymorphic, disease-associated locus varies in natural populations and the extent to which such loci influence the evolutionary trajectories of neutral loci that are physically close on the chromosome (hitchhiking).

这项研究将继续使用称为宇宙文库的基因组资源来详细研究鸟类主要的组织相容性复合物（MHC）中基因的演变。 MHC是与抗病性和自然种群易感性相关的遗传基因座。 可以将该基因座的进化过程与其他脊椎动物组的过程，尤其是哺乳动物的过程进行比较，尤其是哺乳动物，这些过程是整个基因组项目的一部分进行了全面研究的。 还将研究MHC内部和外部的基因座的遗传变异性，以了解MHC内变异性水平的升高是否是由于杂合优势引起的，而不是非编码的中性区域中的相反水平。 最后，将分析编码和非编码区域之间的遗传联系程度。宇宙文库提供的资源将允许在遗传上较少的鸣禽物种中进行多种种群遗传研究。这些研究对于理解高度多态性，与疾病相关的基因座如何在自然种群中有所不同，以及该基因座影响中性基因座的进化轨迹的程度，这些基因座的进化轨迹在物理上接近染色体（Hitchhiking）。