US Austria-Denmark Cooperative Research: Modeling and Control of the Cardiovascular-Respiratory System

美国奥地利-丹麦合作研究：心血管-呼吸系统的建模与控制

• 批准号: 0437037
• 负责人: Mette Olufsen
• 金额: --
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0437037&HistoricalAwards=false
• 关键词: US; Austria; Denmark; Cooperative; Research

0437037OlufsenThis award supports the development of a mathematical model predicting short-term cardiovascular regulation during orthostatic stress and hypovolemia. The model to be derived will contain three sub-models: A cardiovascular model predicting blood pressure and flow in the cardiovascular system, a model predicting sympathetic and parasympathetic activity of the autonomic nervous system, and a model predicting concentrations of carbon dioxide and oxygen. These models will be combined through models for autonomic regulation and autoregulation. In addition, formal statistical and computational methods will be used to estimate parameters in the models with emphasis on accounting for and exploring variability underlying mechanisms across different individuals. In particular, the mathematical model will be validated against already existing data from hypovolemia and orthostatic stress tests, obtained during postural change from sitting to standing, head up tilt, and lower body negative pressure.This research project is a collaborative effort between the PIs, J. Ottesen of Denmark, and J. Batzel and F. Kappel of Austria. In the past, each group has conducted successful research projects in related areas. With the attention and expertise of the US and foreign groups focused on this project, the collaboration will make significant progress in this area of research.In order to enhance antihypertensive therapy, further knowledge of the effects of aging and hypertension on the cerebral circulation is essential. Since recent studies show a relationship between hypertension and development of cognitive dysfunction, it is crucial to understand the effect of hypertension on cerebral perfusion. Despite the importance of these clinical questions, progress towards answering them has been impeded by inadequate non-invasive methods to measure cerebral autoregulation, and inadequately tested assumptions about cerebral vasomotion. This award will support research designed to aid in the detection and remediation of these and other potentially life threatening injuries or conditions.

0437037Olufsen该奖项支持开发预测直立性应激和低血容量期间短期心血管调节的数学模型。 要导出的模型将包含三个子模型：预测心血管系统血压和流量的心血管模型、预测自主神经系统交感神经和副交感神经活动的模型以及预测二氧化碳和氧气浓度的模型。这些模型将通过自主调节和自动调节模型结合起来。 此外，将使用正式的统计和计算方法来估计模型中的参数，重点是考虑和探索不同个体之间潜在机制的变异性。 特别是，数学模型将根据低血容量和体位压力测试的现有数据进行验证，这些数据是在从坐到站的姿势变化、头部倾斜和下半身负压期间获得的。该研究项目是 PI 之间的合作成果，丹麦的 J. Ottesen、奥地利的 J. Batzel 和 F. Kappel。 过去，每个小组都在相关领域开展了成功的研究项目。 凭借美国和外国团体对该项目的关注和专业知识，此次合作将在这一研究领域取得重大进展。为了加强抗高血压治疗，进一步了解衰老和高血压对脑循环的影响至关重要。 由于最近的研究表明高血压与认知功能障碍的发展之间存在关系，因此了解高血压对脑灌注的影响至关重要。 尽管这些临床问题很重要，但由于测量脑自动调节的非侵入性方法不充分，以及对脑血管舒缩的假设检验不充分，阻碍了回答这些问题的进展。 该奖项将支持旨在帮助检测和补救这些和其他可能危及生命的伤害或状况的研究。