Fundamental Studies of Ion Formation from Charged and Neutral Drops with Applications to Gas Phase Ion Chemistry and Chemical Analysis

带电和中性液滴形成离子的基础研究及其在气相离子化学和化学分析中的应用

• 批准号: 0416381
• 负责人: Jesse Beauchamp
• 金额: --
• 依托单位: California Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2010-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0416381&HistoricalAwards=false
• 关键词: Fundamental; Studies; Ion; Formation; Charged

J. L. Beauchamp of the California Institute of Technology is supported by the Analytical and Surface Chemistry Program to study the mechanism of ion formation from charged and neutral drops with applications to gas phase ion chemistry and chemical analysis. Frontier research is planned in three areas, including (1) continued studies of the mechanism of desolvated ion formation from small charged droplets, expected to provide greater insights into the process of ion formation in electrospray ionization (ESI) (2) a new initiative to characterize a novel method developed in the PI laboratory using field induced droplet ionization (FIDI), to extract molecular ions and clusters from neutral droplets, based on neutral droplet instability in strong electric fields and (3) application of these methods to studies ranging from environmental analysis to nanoparticle chemistry. These studies are expected to lead to new and efficient techniques for ion collection and analysis, with applications that include not only the sensitive detection of biological molecules, but also measurements of explosives, chemical and biological weapons agents, and chemicals of environmental interest.

加利福尼亚技术研究所的J. L. Beauchamp得到了分析和表面化学计划的支持，该计划研究了来自带电和中性滴的离子形成机制，并应用于气相离子化学和化学分析。 计划在三个领域进行边境研究，包括（1）持续研究脱落离子形成的机制，这些液滴的机制有望提供更多的见解，以对电喷雾离子化（ESI）中离子形成的过程（ESI）（2）在PI实验室中发育的新方法，从而在电场诱导的液滴中表征中性离子，从而表征了一个新的方法，从关于强电场中的中性液滴不稳定性以及（3）将这些方法应用于从环境分析到纳米颗粒化学的研究。预计这些研究将为离子收集和分析提供新的和有效的技术，其应用不仅包括对生物分子的敏感检测，还包括爆炸物，化学和生物武器剂以及环境兴趣的化学物质的测量。