Neural mechanisms of reconsolidation blockade in humans

人类再巩固阻断的神经机制

• 批准号: 158251458
• 负责人: Professor Dr. Lars Schwabe
• 金额: --
• 依托单位: Arbeitsgruppe Allgemeine und Biologische Psychologie
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2010-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/158251458?language=en
• 关键词: Neural; mechanisms; reconsolidation; blockade; humans

Reconsolidation refers to the process in which a memory is rendered transiently labile after its reactivation. Recent findings suggest that the β-adrenergic antagonist Propranolol can impede the reconsolidation and thus reduce the strength of intrusive memories believed to cause the symptomatology in Posttraumatic Stress Disorder. However, the neural mechanisms mediating the blockade of emotional memory reconsolidation through Propranolol remain largely unexplored. The present study aims to close this gap. Aversive memories will be established using a fear conditioning paradigm. Seven days later, these fear memories will be reactivated and Propranolol will be administered to block reconsolidation. After another three days, the fear conditioning will be tested to investigate if Propranolol was capable of blocking the reconsolidation. Furthermore, it will be assessed whether the Propranolol effect on reconsolidation is context-specific. Dependent variables include skin conductance responses, heart rate, salivary cortisol, and neural activation changes as measured using fMRI. The results of the proposed project will shed light on the mechanisms by which “a blood pressure drug may dim bad memories” (Sci. Am., 2009).

重新整合是指在重新激活后瞬时标记内存的过程。最近的发现表明，β-肾上腺素拮抗剂普萘洛尔会阻碍重新固定，从而降低被认为会导致创伤后应激障碍症状的侵入性记忆的强度。但是，通过普萘洛尔介导情绪记忆的封锁的封锁的神经元机制在很大程度上仍然是意外的。本研究旨在缩小这一差距。厌恶记忆将使用恐惧调节范式建立。七天后，这些恐惧的记忆将被重新激活，并且将施用普萘洛尔以阻止重新固化。再过三天后，将测试恐惧条件，以调查普萘洛尔是否能够阻止重新溶解。此外，将评估普萘洛尔对重新溶解的影响是否特定于上下文。因变量包括皮肤电导反应，心率，唾液皮质醇以及使用fMRI测量的神经激活变化。拟议项目的结果将阐明“血压药物可能使记忆不好”的机制（Sci。Am。，2009）。