RUI: Applications in Capillary Electrophoresis

RUI：毛细管电泳中的应用

• 批准号: 0136724
• 负责人: Frank Gomez
• 金额: $ 26.89万
• 依托单位: California State L A University Auxiliary Services Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-15 至 2006-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0136724&HistoricalAwards=false
• 关键词: RUI; Applications; Capillary; Electrophoresis

This award to Professor Frank Gomez of the California State University, Los Angeles, is supported by the Analytical and Surface Chemistry Program in the Chemistry Division. A primary objective is to couple on-column reactions with affinity-based separations for the dual purposes of high-throughput synthesis and rapid analysis. In addition, capillary electrophoresis will be further developed to assess binding constants for substrate-protein and substrate-DNA interactions.New analytical techniques are needed for the study of disease and improve public health. The proposed studies will focus on developing these new techniques by examining model biological systems with the long-term goal of developing useful techniques to study diseases including cancer, Alzheimer's, and Parkinsons. In addition, the proposed research effort will provide undergraduate and minority students a solid background in chemistry by examining problems at the interface of chemistry and chemistry-related disciplines. The research projects planned for the participants are aimed at demonstrating the interdisciplinary nature of CE and its importance as a new and exciting instrument in solving broad scientific problems.

该奖项授予洛杉矶加利福尼亚州立大学的弗兰克·戈麦斯（Frank Gomez）教授，得到了化学部的分析和表面化学计划的支持。 一个主要目的是将基于亲和力的分离进行近构成反应，以进行高通量合成和快速分析的双重目的。 此外，将进一步开发毛细血管电泳，以评估底物 - 蛋​​白质和底物-DNA相互作用的结合常数。需要新的分析技术来研究疾病并改善公共卫生。拟议的研究将通过检查模型生物系统的长期目标来开发有用的技术来研究癌症，阿尔茨海默氏症和帕金森氏症等有用的疾病，以开发这些新技术。 此外，拟议的研究工作将通过检查化学和化学与化学相关学科的界面上的问题，从而为大学生和少数族裔学生提供扎实的化学背景。计划为参与者计划的研究项目旨在证明CE的跨学科性质及其作为解决广泛科学问题的一种新的令人兴奋的工具的重要性。