NER: Microarray Devices of Aligned Carbon Nanotubes for Biological/Biomedical Research

NER：用于生物/生物医学研究的对齐碳纳米管微阵列装置

• 批准号: 0103012
• 负责人: Tsu-Wei Chou
• 金额: $ 10万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0103012&HistoricalAwards=false
• 关键词: NER; Microarray; Devices; Aligned; Carbon

This proposal was received in response to NSE, NSF-0019. The goal of the research is to explore the potential application of carbon nanotubes for greatly enhancing the efficiency of existing microarray devices in biological/biomedical research. The proposed work will synthesize arrays of well-aligned carbon nanotubes that can be used to transfer biomolecules from the tips of the nanotubes for creating microarrays at a level of packing density not achievable by current techniques. Carbon nanotubes are uniquely suited for this application owing to their extremely high elastic modulus and strength as well as exceptional capability in sustaining large nonlinear elastic deformation.This is a preliminary feasibility study of a novel idea in nanoscience and engineering with focuses on nanoscale devices and systems architecture, and modeling and simulation at the nanoscale. The effort is likely to catalyze rapid advances in biological/biomedical research.The objectives of this exploratory research are to (a) better understand the growth of aligned carbon nanotubes for achieving optimal control of their length, diameter, and packing density in microarrays, (b) better understand the structures and performance of individual nanotubes as well as microarrays through microscopic and mechanical characterizations, (c) initiate computational mechanics effort at both the continuum and atomistic levels for modeling the nano-structure, chirality, and mechanical behavior of nanotubes, (d) develop the tools and criteria for assessing the performance of this novel microarray device for biological/biomedical research, and (e) evaluate the feasibility of the nanotube-based microarray devices.It is expected that this project will advance microarray technology to enable more rapid study by biological and biomedical investigators in areas of genetic research. Ultimately,this technology may result in advancements in the study and treatment of human disease. Fundamentalinvestigations on synthesis, characterization, and property modeling of carbon nanotubes will benefit the technology of nanotube synthesis and engineering. Better understanding of nanotube growth mechanisms will enable improved synthesis and control of the nanotube structure. Development of structure/property models for mechanical behavior of carbon nanotubes, along with synthesis/structure relationships, will ultimately provide a tool for engineering their mechanical properties.

该提案是针对 NSE、NSF-0019 的回应而收到的。 该研究的目标是探索碳纳米管的潜在应用，以大大提高现有微阵列设备在生物/生物医学研究中的效率。拟议的工作将合成排列良好的碳纳米管阵列，该阵列可用于从纳米管尖端转移生物分子，从而以当前技术无法实现的堆积密度水平创建微阵列。碳纳米管因其极高的弹性模量和强度以及承受大的非线性弹性变形的卓越能力而特别适合这种应用。这是对纳米科学和工程中的一个新想法的初步可行性研究，重点关注纳米级器件和系统建筑、纳米尺度的建模和模拟。这项努力可能会促进生物/生物医学研究的快速进展。这项探索性研究的目标是（a）更好地了解排列碳纳米管的生长，以实现微阵列中其长度、直径和堆积密度的最佳控制，（ b）通过微观和机械表征更好地了解单个纳米管以及微阵列的结构和性能，（c）在连续体和原子水平上启动计算力学工作，以对纳米结构、手性进行建模，和纳米管的机械行为，（d）开发用于评估这种新型微阵列装置用于生物/生物医学研究的性能的工具和标准，以及（e）评估基于纳米管的微阵列装置的可行性。预计该项目将推进微阵列技术，使生物和生物医学研究人员能够在基因研究领域进行更快速的研究。最终，这项技术可能会促进人类疾病的研究和治疗的进步。碳纳米管的合成、表征和性能建模的基础研究将有利于纳米管合成和工程技术。更好地了解纳米管生长机制将有助于改进纳米管结构的合成和控制。碳纳米管机械行为的结构/性能模型的开发以及合成/结构关系最终将提供设计其机械性能的工具。