CAREER: Receptor Mediated Circular Dichroism Spectroscopy

职业：受体介导的圆二色光谱

• 批准号: 0094131
• 负责人: Babak Borhan
• 金额: --
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0094131&HistoricalAwards=false
• 关键词: CAREER; Receptor; Mediated; Circular; Dichroism

With this CAREER award the Organic and Macromolecular Chemistry Program supports the work of Dr. Babek Borhan of the Department of Chemistry at Michigan State University in East Lansing, Michigan. The purpose of the work is to develop a set of host molecules, containing linked tetraaryl porphyrin zinc complexes, which can coordinate to a guest chiral Lewis base (such as an amine) in such a way that the circular dichroism spectrum of the assembly indicates the chirality of the base. The Exciton Coupled Circular Dichroism (ECCD) involved gives a bisignate CD spectrum, which is positive or negative depending only on the absolute stereochemical orientation of the electric transition dipole moment of the interacting chromophores.Dr. Borhan hopes to develop a spectroscopic reporting system which can be used to rapidly determine whether chiral organic compounds (compounds whose mirror images are different, like left and right hands) are left or right handed. This capability could be quite important, especially in view of the importance of chiral compounds in pharmaceuticals and biology. In addition to the graduate students who will be involved in the research, Dr. Borhan will establish an American Chemical Society affiliated SEED program, which will bring high school students from financially disadvantaged families into the lab for summer research experiences.

凭借这一职业奖，有机和高分子化学项目支持密歇根州立大学化学系 Babek Borhan 博士的工作。 这项工作的目的是开发一组包含连接的四芳基卟啉锌配合物的主体分子，它们可以与客体手性路易斯碱（例如胺）配位，使得组装体的圆二色光谱表明碱基的手性。 所涉及的激子耦合圆二色性 (ECCD) 给出了双符号 CD 光谱，其正或负仅取决于相互作用的发色团的电跃迁偶极矩的绝对立体化学方向。博尔汉希望开发一种光谱报告系统，可用于快速确定手性有机化合物（镜像不同的化合物，如左手和右手）是左手还是右手。 这种能力可能非常重要，特别是考虑到手性化合物在药物和生物学中的重要性。 除了参与研究的研究生之外，Borhan 博士还将建立美国化学会附属 SEED 计划，该计划将把来自经济困难家庭的高中生带到实验室进行暑期研究体验。