CAREER: Molecular and mesoscopic Modeling of Somatic Mutations and the Progression of B-cell Malignancies

职业：体细胞突变和 B 细胞恶性肿瘤进展的分子和介观建模

• 批准号: 0093769
• 负责人: Fernando Escobedo
• 金额: $ 37.5万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0093769&HistoricalAwards=false
• 关键词: CAREER; Molecular; mesoscopic; Modeling; Somatic; CAREER; Molecular; mesoscopic; Modeling; Somatic

Objectives: The PI's research objectives are: to develop a multiscale modeling approach to help elucidate: (i) the way in which amino acid sequence and binding affinity of antibodies are correlated and evolve during the humoral immune response to specific antigens, and (ii) to explore the role of somatic mutation and antigen pressure on the evolution of specific B-cell cancers, in particular, of follicular lymphomas.His educational objectives include: (1) undergraduate students are exposed to and trained in molecular modeling techniques, (2) graduate students are trained in multidisciplinary approaches to interdisciplinary problems, (3) the use of disparate length-scale modeling approaches is emphasized, and (4) the educational objectives are well integrated with the research activities.

目的：PI的研究目标是：开发一种多尺度建模方法来帮助阐明：（i）在对特定抗原的体液免疫反应期间相关的氨基酸序列和抗体的结合亲和力的方式，以及（ii）（ii）探索对特定的B-Celliord of cancers of cancers of cancers的作用，以探索can的作用。教育目标包括：（1）本科生接受了分子建模技术和培训，（2）研究生接受了跨学科问题的多学科方法的培训，（3）强调了不同长度规模的建模方法的使用，以及（4）教育目标与研究活动充分融为一体。