Small-Molecule Induced Protein Dimerization: Tetracycline

小分子诱导蛋白质二聚化：四环素

• 批准号: 9977402
• 负责人: Virginia Cornish
• 金额: $ 4万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9977402&HistoricalAwards=false
• 关键词: Small; Molecule; Induced; Protein; Dimerization

This starter grant award of the Special Projects Office of the Chemistry Division supports the research of Professor Virginia Cornish at Columbia University. The theme of the research is the development of dexamethasone-tetracycline as an H1-H2 pair of chemical handles capable of inducing protein dimerization in vivo with high efficiency. The need for efficient catalysts is fundamental to chemistry. Biological catalysts drive cellular processes, and the chemical industry relies on catalysts for the synthesis of compounds ranging from pharmaceuticals to materials. In this project proteins, which are remarkable catalysts for a broad array of reactions, will be designed using combinatorial techniques, which allow large pools of protein variants to be generated and screened simultaneously. A selection strategy that is both a direct screen for catalysis and can be applied to many different reaction types, will be developed.

该化学部特别项目办公室的首发赠款奖支持哥伦比亚大学弗吉尼亚州康沃尔教授的研究。 这项研究的主题是地塞米松四环素作为H1-H2对的一对化学柄，能够以高效率诱导体内蛋白质二聚化。 对有效催化剂的需求是化学基础。 生物催化剂驱动细胞过程，化学工业依靠催化剂来合成从药物到材料的化合物。 在这个项目蛋白中，将使用组合技术设计，这是广泛反应的显着催化剂，这些蛋白质可以同时生成和筛选大量的蛋白质变体。 既是催化的直接筛选，又可以应用于许多不同的反应类型的选择策略。