Conference: The 1999 ASCB/EMBO Meeting, "Membrane Trafficking & the Cytoskeleton": An Integrated View, to be held June 26-30, 1999, in Santa Maria Imbaro, Italy

会议：1999 年 ASCB/EMBO 会议，“膜贩运

• 批准号: 9901126
• 负责人: Elizabeth Marincola
• 金额: $ 0.8万
• 依托单位: American Society For Cell Biology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9901126&HistoricalAwards=false
• 关键词: Conference; 1999; ASCB; EMBO; Meeting

This meeting represents an opportunity to bring together, for the first time, two largely distinct groups whose research efforts have been aimed at a common topic for many years. That topic is membrane transport, particularly within the secretory and endocytotic pathways. Membrane transport can be regarded as a two-sided coin. One side is being studied by traditional membrane "traffickers". The work of this group has been focused on the identification and characterization of regulatory factors for the budding and excision of transport intermediates from donor membranes, and the targeting, docking and fusion of those intermediates to acceptor membranes. Well known examples of factors involved in these processes include COPs, SNAPs, SNAREs, NSF and a variety of GTPases. The other side of the membrane transport coin is being investigated by "motorists". This group has been primarily concerned with the cytoskeletal structures, molecular motors and linker proteins that control how endomembrane compartments are spatially organized within the cytoplasm, and serve as highways along which transport vesicles move between donor and acceptor compartments. Most work in this area has focused on microtubules, and motor proteins of the kinesin and dynein families, but recent studies have also emphasized the importance of microfilaments and myosin motors in membrane transport. The development of a comprehensive understanding of membrane transport will require integration of data obtained both by the traffickers and the motorists. The primary goal of the meeting, therefore, is to bridge the gap of understanding and appreciation that presently separates the two groups. Bringing together traffickers and motorists at the same place and time will provide an unprecedented opportunity for exchange of information and cross-fertilization of ideas in the rapidly progressing field of membrane transport.

这次会议代表了一个机会，首次将两个截然不同的群体汇集在一起​​，他们的研究工作一直针对一个共同的话题多年。 该主题是膜运输，尤其是在分泌和内吞途径中。 膜运输可以视为双面硬币。 传统膜“贩运者”正在研究一侧。 该组的工作集中在鉴定和表征供体膜中传输中间体的调节因素以及这些中间体对受体膜的靶向，对接和融合的靶向，对接和融合。 这些过程中涉及的因素的众所周知的例子包括COP，快照，小麻网，NSF和各种GTPase。 “驾车者”正在研究膜运输硬币的另一侧。 该组主要与控制内膜隔室在细胞质内空间组织的细胞骨架结构，分子电机和接头蛋白有关，并用作供体囊泡在供体和受体区室之间移动的高速公路。 该领域的大多数工作都集中在微管上，以及驱动蛋白和动力蛋白家族的运动蛋白，但最近的研究也强调了微丝和肌球蛋白电动机在膜运输中的重要性。 对膜运输的全面理解的发展将需要整合贩运者和驾驶者获得的数据。 因此，会议的主要目标是弥合目前将两组分开的理解和欣赏差距。 将贩运者和驾车者聚集在同一地点和时间，将为媒体运输迅速发展领域中的信息交换和思想交叉侵入提供前所未有的机会。