CAREER: Molecular Rhenium(V) Oxotransferases

职业：分子铼(V) 氧化转移酶

• 批准号: 9874857
• 负责人: Mahdi Abu-Omar
• 金额: $ 33.15万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-15 至 2003-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9874857&HistoricalAwards=false
• 关键词: CAREER; Molecular; Rhenium; Oxotransferases

This CAREER award in the Inorganic, Bioinorganic, and Organometallic Chemistry Program supports research and education on oxygen transfer reactions by Dr. Mahdi M. Abu-Omar of the Chemistry Department, University of California - Los Angeles. New rhenium-based catalysts will be prepared and used to enhance the oxygen-transfer chemistry of sulfoxides. The catalytic reactions of complexes of the general formula ReOCl3LL' will be studied in detail using spectroscopic and kinetic methods. Density Functional Theory calculations on model systems will be used to understand the catalytic reactivities. Using the results, chiral Re(V) oxazoline complexes that are resistant to degradation will be designed in order to promote asymmetric oxo-transfer reactions. Efficient new catalysts will be developed for the asymmetric epoxidation of olefins by sulfoxides. The educational component of this CAREER Award will focus on incorporating contemporary research issues into undergraduate classes in inorganic chemistry and new approaches to problem sessions will be developed.

该职业奖在无机，生物促和有机金属化学计划中支持加利福尼亚大学化学系的Mahdi M. Abu -Omar博士对氧气转移反应的研究和教育。 将准备新的基于Rhenium的催化剂，并用于增强亚氧化氧化物的氧转移化学。 将使用光谱和动力学方法详细研究一般公式Reocl3ll'复合物的催化反应。 模型系统上的密度功能理论计算将用于了解催化反应性。 使用结果，将设计具有抗降解能力的恶唑氨酸络合物，以促进不对称的氧转移反应。 将开发有效的新催化剂，以通过亚硫氧化物对烯烃的不对称环氧化。 该职业奖的教育组成部分将着重于将当代研究问题纳入无机化学的本科班级，并将开发出新的问题课程方法。