POWRE: Exploring Novel Methods to Quantify Fluid Flow in Mechanically Loaded Bone

POWRE：探索量化机械负载骨骼中流体流动的新方法

• 批准号: 9806202
• 负责人: Susannah Fritton
• 金额: $ 7.5万
• 依托单位: CUNY City College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-10-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9806202&HistoricalAwards=false
• 关键词: POWRE; Exploring; Novel; Methods; Quantify

9806202FrittonThe objectives of this research are to perform pilot experiments to begin to test the validity of recently developed theoretical models of bone fluid flow and electrical signal transduction in the lacunar-canalicular porosity of bone. These experiments include exploring novel methods to: (1) measure the microstructural electrical potentials and bone fluid flow produced in loaded bone tissue samples as a function of loading frequency, and (2) quantify the resulting transmembrane and intracellular potentials that pass down the processes of the osteocytic bone cells. This research is appropriate for the POWRE program because it will permit the principal investigator to become established in a new area of research which will further her career advancement.***

9806202Fritton这项研究的目的是进行试验实验，以开始测试骨流体流量和骨骼流体流动的理论模型的有效性和骨骼孔隙孔隙率的骨流体流量和电信号转导的有效性。 这些实验包括探索以下新方法：（1）测量在负载骨组织样品中产生的微结构电势和骨流体流作为负载频率的函数，以及（2）量化所得的跨膜和细胞内电势，这些跨膜和细胞内电位通过降低了骨细胞的过程。 这项研究适合POWRE计划，因为它将允许主要研究人员在新的研究领域建立，这将进一步发展她的职业发展。***