Local and Central Control Mechanisms in the Barorecptor Vagal Reflex with Neuromorphic Engineering Applications to Chemical Process Control

压力感受器迷走神经反射的局部和中央控制机制与神经形态工程在化学过程控制中的应用

• 批准号: 9712820
• 负责人: Francis Doyle
• 金额: $ 25.43万
• 依托单位: Purdue Research Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-15 至 2000-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9712820&HistoricalAwards=false
• 关键词: Local; Central; Control; Mechanisms; Barorecptor

9712820 Doyle The aim of this research is to perform reverse engineering of the baroreceptor control mechanism to develop practical process control algorithms. The primary role of the baroreceptor reflex mechanism is the modulation of blood pressure by regulating heart rate on a short time frame. From a systems perspective, the heart is a massively instrumented actuator with multiple hierarchical effector signals from the central nervous system, complex local circuitry, and has as a primary objective the regulation of blood pressure. In particular, the investigators plan to study local control loops in the baroreceptor reflex. They propose that these local loops, which function independently of the central nervous system, can be emulated and applied to real-world process control problems. The investigators will map out motor cardiac fibers associated with the baroreceptor reflex by using fluorescent labeling and confocal microscopy. The local control loops in the reflex would be carefully analyzed in order to develop a theoretical formulation for locally intelligent control algorithms. These algorithms would be applied to a difficult polymerization reactor control problem and to local control valve actuation to overcome performance degradation due to wear or mechanical failure. The reactor control problem concerns a difficult polymerization grade transition problem, where the temperature is periodically changed to alter the free radical polymerization of ethylene in a reactor. This system is subject to an extinction phenomena if the reactor temperature exceeds a lower limit. The intelligent controller of this research would be used to obtain tight control while avoiding extinction. ***

9712820 Doyle 这项研究的目的是对压力感受器控制机制进行逆向工程，以开发实用的过程控制算法。 压力感受器反射机制的主要作用是通过在短时间内调节心率来调节血压。 从系统角度来看，心脏是一个大型仪器执行器，具有来自中枢神经系统的多个分层效应器信号、复杂的局部电路，并且其主要目标是调节血压。 研究人员特别计划研究压力感受器反射的局部控制环路。 他们提出，这些独立于中枢神经系统运行的局部循环可以被模拟并应用于现实世界的过程控制问题。 研究人员将通过荧光标记和共聚焦显微镜绘制出与压力感受器反射相关的运动心肌纤维。 将仔细分析反射中的局部控制回路，以便开发局部智能控制算法的理论公式。 这些算法将应用于困难的聚合反应器控制问题和局部控制阀驱动，以克服由于磨损或机械故障而导致的性能下降。 反应器控制问题涉及困难的聚合级转变问题，其中周期性地改变温度以改变反应器中乙烯的自由基聚合。 如果反应器温度超过下限，该系统就会出现熄灭现象。 这项研究的智能控制器将用于获得严格的控制，同时避免灭绝。 ***