Peptide Delivery to Cell Cultures Using Intelligent Polymers
使用智能聚合物将肽递送至细胞培养物
基本信息
- 批准号:9707652
- 负责人:
- 金额:$ 5.94万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-09-01 至 1998-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
9707652 Brown This is a promising new investigator in the field of biomaterials and tissue engineering. She has great potential to become a fine scientist. Funding of this proposal is expected to advance the PI's career and meet the goals of this program. The proposed research investigates novel polymers that swell and collapse in response to electrical stimuli. These materials may be useful for modulated drug delivery. The PI has already constructed a prototype of the electrorelease chamber used in these studies and has an appropriate background to conduct the proposed studies. In addition to potential drug delivery applications, the proposed technology may be useful for in vitro evaluation of cellular responses to various substances. As technical notes, LDH is a crude measure of cytotoxicity and biocompatibility, as it detects rupture of cell membranes. Changes in insulin production, cell metabolism, etc. will be observed long before membrane rupture. Inclusion of a diagram of the electrorelease chamber would have been helpful, in that the photograph provided was not very clear. ***
9707652 Brown这是生物材料和组织工程领域中有希望的新研究者。 她有很大的潜力成为一名优秀的科学家。 预计该提案的资金将推进PI的职业生涯并实现该计划的目标。 拟议的研究调查了对电刺激的响应膨胀和崩溃的新型聚合物。 这些材料可能可用于调制药物输送。 PI已经构建了这些研究中使用的电子释放室的原型,并且具有适当的背景来进行拟议的研究。 除了潜在的药物递送应用外,该提出的技术可能对体外评估细胞对各种物质的反应。 正如技术指出的那样,LDH是细胞毒性和生物相容性的粗略度量,因为它检测到细胞膜破裂。 在膜破裂之前,将观察到胰岛素产生,细胞代谢等的变化。 包括电子发行室的图表将很有帮助,因为所提供的照片并不清楚。 ***
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

暂无数据
数据更新时间:2024-06-01
Kimberly Brown其他文献
Traumatic Brain Injury and Risk of Schizophrenia and Other Non-mood Psychotic Disorders: Findings From a Large Inpatient Database in the United States.
创伤性脑损伤和精神分裂症和其他非情绪性精神病的风险:来自美国大型住院患者数据库的调查结果。
- DOI:
- 发表时间:20242024
- 期刊:
- 影响因子:6.6
- 作者:C. Trivedi;Preetam Reddy;Abida Rizvi;Karrar Husain;Kimberly Brown;Zeeshan Mansuri;Mahamudun Nabi;Shailesh JainC. Trivedi;Preetam Reddy;Abida Rizvi;Karrar Husain;Kimberly Brown;Zeeshan Mansuri;Mahamudun Nabi;Shailesh Jain
- 通讯作者:Shailesh JainShailesh Jain
Acute Skin Graft Versus Host Disease Post Liver Transplantation: A Case Report
- DOI:10.1016/j.bbmt.2014.11.51510.1016/j.bbmt.2014.11.515
- 发表时间:2015-02-012015-02-01
- 期刊:
- 影响因子:
- 作者:Mohammad Alhyari;Aymen Bukannan;Kimberly Brown;Shatha Farhan;Edward Peres;Nalini JanakiramanMohammad Alhyari;Aymen Bukannan;Kimberly Brown;Shatha Farhan;Edward Peres;Nalini Janakiraman
- 通讯作者:Nalini JanakiramanNalini Janakiraman
Development of an operating room assessment tool for medical students on their surgery clerkship
为医学生的外科见习开发手术室评估工具
- DOI:
- 发表时间:20232023
- 期刊:
- 影响因子:0
- 作者:Catherine McManus;Sophie E. Mayeux;Roman Nowygrod;Kimberly BrownCatherine McManus;Sophie E. Mayeux;Roman Nowygrod;Kimberly Brown
- 通讯作者:Kimberly BrownKimberly Brown
Mo1395 - Marked Impact of Revised Hepatitis C Screening Guidelines with Electronic Medical Record Prompt on Screening of the 'Baby Boomer Cohort' by Primary Care Physicians
- DOI:10.1016/s0016-5085(17)33905-710.1016/s0016-5085(17)33905-7
- 发表时间:2017-04-012017-04-01
- 期刊:
- 影响因子:
- 作者:Johnathon Markus;Omar Sadiq;David Nerenz;Nonna Akkerman;Sara Stanley;Kimberly Brown;Dilip MoonkaJohnathon Markus;Omar Sadiq;David Nerenz;Nonna Akkerman;Sara Stanley;Kimberly Brown;Dilip Moonka
- 通讯作者:Dilip MoonkaDilip Moonka
RESEARCH STUDIES IN HIGHER EDUCATION: EDUCATING MULTICULTURAL COLLEGE STUDENTS-Ch 8
- DOI:
- 发表时间:20122012
- 期刊:
- 影响因子:0
- 作者:Kimberly BrownKimberly Brown
- 通讯作者:Kimberly BrownKimberly Brown
共 23 条
- 1
- 2
- 3
- 4
- 5
相似国自然基金
酶响应的中性粒细胞外泌体载药体系在眼眶骨缺损修复中的作用及机制研究
- 批准号:82371102
- 批准年份:2023
- 资助金额:49.00 万元
- 项目类别:面上项目
O2O模式下有服务等级的即时取送货在线调度策略研究
- 批准号:
- 批准年份:2021
- 资助金额:30 万元
- 项目类别:青年科学基金项目
O2O模式下有服务等级的即时取送货在线调度策略研究
- 批准号:72101196
- 批准年份:2021
- 资助金额:24.00 万元
- 项目类别:青年科学基金项目
应用RNA-only delivery基因回路靶向治疗CMS2型结肠癌的研究
- 批准号:82003254
- 批准年份:2020
- 资助金额:16.0 万元
- 项目类别:青年科学基金项目
基于不确定网购行为的“送货上门”配送优化策略与算法
- 批准号:71671152
- 批准年份:2016
- 资助金额:48.0 万元
- 项目类别:面上项目
相似海外基金
Mechanisms of Mammalian Genetic Hearing Loss
哺乳动物遗传性听力损失的机制
- 批准号:1066013410660134
- 财政年份:2023
- 资助金额:$ 5.94万$ 5.94万
- 项目类别:
Development of peptide drug conjugates for cancer therapy
开发用于癌症治疗的肽药物缀合物
- 批准号:1076023610760236
- 财政年份:2023
- 资助金额:$ 5.94万$ 5.94万
- 项目类别:
ModRNA-based Direct Programming of Universal Donor hiPSCs into Immune Evasive Beta Cells
基于 ModRNA 的通用供体 hiPSC 直接编程至免疫逃避型 β 细胞
- 批准号:1077436110774361
- 财政年份:2023
- 资助金额:$ 5.94万$ 5.94万
- 项目类别:
Engineering the open porous nanofibrous microsphere integrated fibrillar hydrogel for the co-delivery of antibacterial and angiogenic agents aimed at the rapid diabetic wound repair
设计开放多孔纳米纤维微球集成纤维水凝胶,用于共同递送抗菌剂和血管生成剂,旨在快速修复糖尿病伤口
- 批准号:1073711510737115
- 财政年份:2023
- 资助金额:$ 5.94万$ 5.94万
- 项目类别:
Trans-synaptic optical control of user-defined synaptic connections
用户定义的突触连接的跨突触光学控制
- 批准号:1073208110732081
- 财政年份:2023
- 资助金额:$ 5.94万$ 5.94万
- 项目类别: