Finding Similar Folds Between Three-Dimensional Protein Structures by Dihedral Sequence Comparison

通过二面体序列比较寻找三维蛋白质结构之间的相似折叠

• 批准号: 9701577
• 负责人: Leandra Vicci
• 金额: $ 36.99万
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-15 至 1999-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9701577&HistoricalAwards=false
• 关键词: Finding; Similar; Folds; Between; Three

This project is investigating applications of dihedral sequence comparison (DISCO) to protein structure comparison and protein folding problems. DISCO transforms atomic coordinates into one-dimensional dihedral sequences, then applies the BioSCAN sequence alignment computer to find segments with similar three-dimensional folds. The goals of the DISCO project include: (1) exploring new algorithms and representations of the three-dimensional structures of folded proteins by one-dimensional sequences; (2) exploring the use of the BioSCAN system to compare these sequences; (3) developing statistically-based scores for measuring the structural similarity of folded protein segments by comparing their dihedral sequences; (4) developing a robust computational system based on BioSCAN for protein structure analysis; and (5) making the DISCO system available over the Internet to the scientific community.

该项目正在研究二面体序列比较（DISCO）在蛋白质结构比较和蛋白质折叠问题中的应用。 DISCO 将原子坐标转换为一维二面体序列，然后应用 BioSCAN 序列比对计算机来查找具有相似三维折叠的片段。 DISCO项目的目标包括：（1）探索新的算法和通过一维序列表示折叠蛋白质的三维结构； (2)探索使用BioSCAN系统来比较这些序列； (3) 开发基于统计的评分，通过比较折叠蛋白片段的二面体序列来测量其结构相似性； (4) 开发基于BioSCAN的强大计算系统，用于蛋白质结构分析； (5) 通过互联网向科学界提供 DISCO 系统。