Finding Similar Folds Between Three-Dimensional Protein Structures by Dihedral Sequence Comparison

通过二面体序列比较寻找三维蛋白质结构之间的相似折叠

• 批准号: 9701577
• 负责人: Leandra Vicci
• 金额: $ 36.99万
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-15 至 1999-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9701577&HistoricalAwards=false
• 关键词: Finding; Similar; Folds; Between; Three

This project is investigating applications of dihedral sequence comparison (DISCO) to protein structure comparison and protein folding problems. DISCO transforms atomic coordinates into one-dimensional dihedral sequences, then applies the BioSCAN sequence alignment computer to find segments with similar three-dimensional folds. The goals of the DISCO project include: (1) exploring new algorithms and representations of the three-dimensional structures of folded proteins by one-dimensional sequences; (2) exploring the use of the BioSCAN system to compare these sequences; (3) developing statistically-based scores for measuring the structural similarity of folded protein segments by comparing their dihedral sequences; (4) developing a robust computational system based on BioSCAN for protein structure analysis; and (5) making the DISCO system available over the Internet to the scientific community.

该项目正在研究二面序列比较（迪斯科）与蛋白质结构比较和蛋白质折叠问题的应用。 迪斯科将原子坐标转换为一维二面序列，然后应用Bioscan序列比对计算机以找到具有相似三维折叠的段。 迪斯科项目的目标包括：（1）通过一维序列探索折叠蛋白的三维结构的新算法和表示； （2）探索使用Bioscan系统比较这些序列的使用； （3）开发基于统计的分数，用于通过比较其二面序列来测量折叠蛋白段的结构相似性； （4）开发基于Bioscan的强大计算系统进行蛋白质结构分析； （5）使迪斯科系统通过互联网提供给科学界。