Molecular insights into lipid-mediated T cell immunity

脂质介导的 T 细胞免疫的分子见解

基本信息

批准号：
DE230101042
负责人：
Dr Praveena Thirunavukkarasu
金额：
$ 29.7万
依托单位：
Monash University
依托单位国家：
澳大利亚
项目类别：
Discovery Early Career Researcher Award
财政年份：
2023
资助国家：
澳大利亚
起止时间：
2023-01-01 至 2025-12-31
项目状态：
未结题

来源：
https://dataportal.arc.gov.au/RGS/Web/Grants/DE230101042
关键词：
Molecular insights into lipid mediated

Molecular insights into lipid mediated

项目摘要

This project involves the discovery of novel lipids produced by the microbiome that play a significant role in T cell-mediated immunity. Using a combination of cutting-edge technologies such as mass spectrometry, protein crystallography, immunology and biophysics, this project will elucidate the molecular factors that govern the interaction between the identified lipids and T cells. This innovative research will provide fundamental insights into the recognition mechanism of lipids by T cells at a molecular level, thus broadening our knowledge in the field of biological sciences. The expected research outcomes will increase Australia’s international research standing in this burgeoning area of lipid-mediated T cell immunity.

该项目涉及发现微生物组产生的新型脂质，这些脂质在T细胞介导的免疫共同体中起着重要作用。该项目结合了质谱，蛋白质晶体学，免疫学和生物物理学等尖端技术的结合，该项目将阐明控制已确定的脂质与T细胞之间相互作用的分子因子。这项创新的研究将提供对T细胞在分子水平上脂质识别机制的基本见解，从而扩大我们在生物科学领域的知识。预期的研究成果将增加澳大利亚在脂质介导的T细胞免疫力的新兴地区的国际研究。