The Inverse Problem of Electrocardiography: New Computational Approaches, Numerical Simulations, and Experimental Verification

心电图反问题：新的计算方法、数值模拟和实验验证

• 批准号: 9410385
• 负责人: Robert Throne
• 金额: $ 27.04万
• 依托单位: University of Nebraska-Lincoln
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-15 至 1998-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9410385&HistoricalAwards=false
• 关键词: Inverse; Problem; Electrocardiography; New; Computational

9410385 Throne The research proposed in this application is concerned with a recently developed generalized eigensystem finite element technique for the inverse problem of electrocardiography will be extended, compared with other existing methods and validated by comparison with experimental results. Preliminary results indicate that the new generalized eigensystem method performs better than existing approaches on a previously reported eccentric spheres model problem with anterior and posterior spherical cap sources. This generalized eigensystem technique will first be applied to the inhomogeneous eccentric spheres problem and then to a realistic human torso model with realistic human epicardial potentials. With both models the effects of errors in estimating the conductivities, errors in the anisotropic properties, and geometrical errors will be examined and compared with previously reported methods. In addition, the techniques will be validated and compared with experimental results from an isolated rabbit heart preparation. Computational issues such as improved spectral finite elements, robustness, accuracy, and efficiency will be considered. ***

9410385王位本应用程序中提出的研究与最近开发的广义特征系统有限元技术有关电动心电图的逆问题，将扩展与其他现有方法相比，并通过与实验结果进行比较验证。 初步结果表明，在先前报道的偏心球模型问题上，新的广义特征系统方法的性能优于现有方法，并具有前球形帽源和后端球形盖。 这种广义的特征系统技术将首先应用于不均匀的怪异领域问题，然后应用于具有逼真的人性心外膜潜力的现实人躯干模型。 两种模型都将检查误差在估计电导率，各向异性特性中的误差以及几何误差的效果，并将与先前报道的方法进行检查。 此外，这些技术将得到验证，并将其与孤立的兔心脏制剂的实验结果进行了比较。 将考虑诸如改善光谱有限元素，鲁棒性，准确性和效率之类的计算问题。 ***