The Inverse Problem of Electrocardiography: New Computational Approaches, Numerical Simulations, and Experimental Verification

心电图反问题：新的计算方法、数值模拟和实验验证

• 批准号: 9410385
• 负责人: Robert Throne
• 金额: $ 27.04万
• 依托单位: University of Nebraska-Lincoln
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-15 至 1998-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9410385&HistoricalAwards=false
• 关键词: Inverse; Problem; Electrocardiography; New; Computational

9410385 Throne The research proposed in this application is concerned with a recently developed generalized eigensystem finite element technique for the inverse problem of electrocardiography will be extended, compared with other existing methods and validated by comparison with experimental results. Preliminary results indicate that the new generalized eigensystem method performs better than existing approaches on a previously reported eccentric spheres model problem with anterior and posterior spherical cap sources. This generalized eigensystem technique will first be applied to the inhomogeneous eccentric spheres problem and then to a realistic human torso model with realistic human epicardial potentials. With both models the effects of errors in estimating the conductivities, errors in the anisotropic properties, and geometrical errors will be examined and compared with previously reported methods. In addition, the techniques will be validated and compared with experimental results from an isolated rabbit heart preparation. Computational issues such as improved spectral finite elements, robustness, accuracy, and efficiency will be considered. ***

9410385 Throne 本申请中提出的研究涉及最近开发的广义特征系统有限元技术，用于心电图反问题，将与其他现有方法进行扩展，并通过与实验结果进行比较进行验证。 初步结果表明，新的广义特征系统方法在处理先前报道的具有前球冠源和后球冠源的偏心球模型问题上比现有方法表现更好。 这种广义特征系统技术将首先应用于非均匀偏心球问题，然后应用于具有真实人类心外膜电位的真实人类躯干模型。 对于这两种模型，将检查电导率估计误差、各向异性特性误差和几何误差的影响，并与以前报道的方法进行比较。 此外，该技术还将得到验证，并与离体兔心脏制剂的实验结果进行比较。 将考虑改进的谱有限元、鲁棒性、准确性和效率等计算问题。 ***