Micromechanics of Cell Activation in Cancer Metastasis

癌症转移中细胞激活的微观力学

• 批准号: 9308809
• 负责人: Cheng Dong
• 金额: $ 11万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-01 至 1997-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9308809&HistoricalAwards=false
• 关键词: Micromechanics; Cell; Activation; Cancer; Metastasis

This Research Initiation grant will allow the investigator to study tumor cell micromotion during chemotactic stimulation through both experimental observations and mathematical modeling. The specific aims are to: 1) develop a system to manipulate tumor cells during pseudopod migration, 2) determine the factors affecting pseudopod protrusion; 3) develop mathematical models for pseudopod formation and cell movement; and 4) correlate pseudopod characteristics with cytoskeletal structure. This research is important since it will contribute towards and understanding of the mechanics of metastases of tumor cells and provide basic information needed to understand physiological processes such as tissue development.

这项研究启动资助将允许研究人员通过实验观察和数学建模来研究趋化刺激过程中肿瘤细胞的微运动。 具体目标是：1）开发一种在伪足迁移过程中操纵肿瘤细胞的系统，2）确定影响伪足突出的因素； 3）开发伪足形成和细胞运动的数学模型； 4) 将伪足特征与细胞骨架结构相关联。 这项研究很重要，因为它将有助于理解肿瘤细胞转移的机制，并提供理解组织发育等生理过程所需的基本信息。