Neurochemical and behavioural characterisation of a novel Dopamine Transporter Deficiency Syndrome mouse model.

新型多巴胺转运蛋白缺乏综合症小鼠模型的神经化学和行为特征。

• 批准号: 372062
• 负责人: Salahpour Ali
• 金额: $ 59.35万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-09-01 至 2022-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=372062&lang=en
• 关键词: Behavioural Pharmacology; Bupropion; Dopamine Transporter; Dopamine Transporter Deficiency Syndrome; Ibogaine; Neurochemistry; Pharmacological Chaperones; Behavioural Pharmacology; Bupropion; Dopamine Transporter; Dopamine Transporter Deficiency Syndrome; Ibogaine; Neurochemistry; Pharmacological Chaperones

Dopamine transmission in the brain is a tightly regulated process, and alterations in dopamine signaling result in several disease with enormous human and economic burden, including schizophrenia, ADHD, Bipolar disorder, Parkinson's disease and dyskinesia

大脑中的多巴胺传播是一个严格调节的过程，多巴胺信号传导的改变导致几种疾病，具有巨大的人类和经济负担，包括精神分裂症，ADHD，双相情感障碍，双相情感障碍，帕金森氏病，帕金森氏病和运动障碍障碍