Interference with Gli to Control Castration Resistant Prostate Cancer

干扰 Gli 控制去势抵抗性前列腺癌

• 批准号: 370743
• 负责人: Buttyan Ralph
• 金额: $ 25.08万
• 依托单位: Vancouver Prostate Centre (BC)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-09-01 至 2020-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=370743&lang=en
• 关键词: Androgen Receptors; Cancer Cell Growth; Cancer Cell Transcriptome; Computerized Small Molecule Docking; Gli Transcription Factors; Hedgehog Signalling; Prostate Cancer; Therapy Resistance; Three-Dimensional Protein Structure; Tumour Growth; Androgen Receptors; Cancer Cell Growth; Cancer Cell Transcriptome; Computerized Small Molecule Docking; Gli Transcription Factors; Hedgehog Signalling; Prostate Cancer; Therapy Resistance; Three-Dimensional Protein Structure; Tumour Growth

Prostate cancer grows and spreads under the influence of androgens (male steroids). For this reason, hormonal therapies are used to treat patients with metastatic disease. Unfortunately, these therapies are only transiently effective; eventually patients

前列腺癌在雄激素（雄性类固醇）的影响下生长并扩散。因此，荷尔蒙疗法用于治疗转移性疾病的患者。不幸的是，这些疗法只有瞬时有效。最终患者