喵ID：spCJYf
Generation and characterization of induced pluripotent stem cells from breast cancer patients carrying ATM mutations. Generation and characterization of induced pluripotent stem cells from breast cancer patients carrying ATM mutations.
Generation and characterization of induced pluripotent stem cells from breast cancer patients carrying ATM mutations.
Generation and characterization of induced pluripotent stem cells from breast cancer patients carrying ATM mutations.基本信息
DOI：
10.1016/j.scr.2023.103246
10.1016/j.scr.2023.103246发表时间：
2023-12
2023-12影响因子：
1.2
1.2通讯作者：
Wu, Joseph C.
Wu, Joseph C.中科院分区：
医学4区
医学4区文献类型：
Journal Article
Journal Article 作者： Zhang, Mao;Venkateshappa, Ravichandra;Li, Audrey;Fowler, Michael B.;Telli, Melinda L.;Wu, Joseph C.
研究方向： Cell Biology;Biotechnology & Applied Microbiology
MeSH主题词： --
关键词： --
来源链接：pubmed详情页地址
文献摘要
We generated two induced pluripotent stem cell (iPSC) lines from peripheral blood mononuclear cells (PBMCs) of breast cancer patients carrying germline ATM mutations, a gene associated with a 7% prevalence in breast cancer. These iPSC lines displayed typical morphology, expressed pluripotency markers, maintained a stable karyotype, and retained the ability to differentiate into the three germ layers. These patient-specific iPSC lines hold great potential for mechanistic investigations and the development of drug screening strategies aimed at addressing ATM-related cancer.
我们从携带种系ATM突变的乳腺癌患者的外周血单个核细胞（PBMC）中生成了两株诱导多能干细胞（iPSC）系，ATM是一种与7%的乳腺癌患病率相关的基因。这些iPSC系呈现出典型的形态，表达多能性标志物，保持稳定的核型，并保留了分化为三个胚层的能力。这些患者特异性的iPSC系在机制研究以及开发旨在解决ATM相关癌症的药物筛选策略方面具有巨大潜力。
参考文献（5）
被引文献（0）
ATM Variants in Breast Cancer: Implications for Breast Radiation Therapy Treatment Recommendations
ATM Variants in Breast Cancer: Implications for Breast Radiation Therapy Treatment RecommendationsDOI：
10.1016/j.ijrobp.2021.01.045
10.1016/j.ijrobp.2021.01.045发表时间：
2021-07-14
2021-07-14影响因子：
7
7作者：
McDuff, Susan G. R.;Bellon, Jennifer R.;Ho, Alice Y.
McDuff, Susan G. R.;Bellon, Jennifer R.;Ho, Alice Y.通讯作者：
Ho, Alice Y.
Ho, Alice Y.The association between ATM variants and risk of breast cancer: a systematic review and meta-analysis.
The association between ATM variants and risk of breast cancer: a systematic review and meta-analysis.DOI：
10.1186/s12885-020-07749-6
10.1186/s12885-020-07749-6发表时间：
2021-01-05
2021-01-05影响因子：
3.8
3.8作者：
Moslemi M;Moradi Y;Dehghanbanadaki H;Afkhami H;Khaledi M;Sedighimehr N;Fathi J;Sohrabi E
Moslemi M;Moradi Y;Dehghanbanadaki H;Afkhami H;Khaledi M;Sedighimehr N;Fathi J;Sohrabi E通讯作者：
Sohrabi E
Sohrabi EGeneration of three heterozygous KCNH2 mutation-carrying human induced pluripotent stem cell lines for modeling LQT2 syndrome
Generation of three heterozygous KCNH2 mutation-carrying human induced pluripotent stem cell lines for modeling LQT2 syndromeDOI：
10.1016/j.scr.2021.102402
10.1016/j.scr.2021.102402发表时间：
2021-05-26
2021-05-26影响因子：
1.2
1.2作者：
Mondejar-Parreno, Gema;Jahng, James W. S.;Wu, Joseph C.
Mondejar-Parreno, Gema;Jahng, James W. S.;Wu, Joseph C.通讯作者：
Wu, Joseph C.
Wu, Joseph C.The ATM Gene in Breast Cancer: Its Relevance in Clinical Practice.
The ATM Gene in Breast Cancer: Its Relevance in Clinical Practice.DOI：
10.3390/genes12050727
10.3390/genes12050727发表时间：
2021-05-13
2021-05-13期刊：
影响因子：
3.5
3.5作者：
Stucci LS;Internò V;Tucci M;Perrone M;Mannavola F;Palmirotta R;Porta C
Stucci LS;Internò V;Tucci M;Perrone M;Mannavola F;Palmirotta R;Porta C通讯作者：
Porta C
Porta CATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles
ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility allelesDOI：
10.1038/ng1837
10.1038/ng1837发表时间：
2006-08-01
2006-08-01影响因子：
30.8
30.8作者：
Renwick, Anthony;Thompson, Deborah;Rahman, Nazneen
Renwick, Anthony;Thompson, Deborah;Rahman, Nazneen通讯作者：
Rahman, Nazneen
Rahman, Nazneen共 5 条
- 1
关联基金
Modeling Tyrosine Kinase Inhibitor-Induced Vascular Dysfunction Using Human iPSCs
批准号：
10646316
10646316批准年份：
2018
2018资助金额：
67.6
67.6项目类别：
