Core-shell magnetic nanoparticles with surface-imprinted polymer coating as a new adsorbent for solid phase extraction of metronidazole

Core-shell magnetic nanoparticles with surface-imprinted polymer coating as a new adsorbent for solid phase extraction of metronidazole

We have prepared a nanoparticle-based metronidazole-imprinted polymer by combining a surface molecular imprinting technique with a sol-gel process. Metronidazole was used as a template, 3-aminoprophyltriethoxysilane as the functional monomer, and tetraethyl orthosilicate as the cross-linker. The resulting magnetic molecularly imprinted polymer was characterized by Fourier transform infrared spectroscopy, powder X-ray diffraction and scanning electron microscopy. The adsorbent can be applied to the solid phase extraction of metronidazole and exhibits high adsorption capacity, good selectivity, favorable reusability and the feature of magnetic separation. The binding performances of the adsorbent were evaluated by equilibrium rebinding experiments and Scatchard analysis. The material was successfully applied to solid phase extraction of metronidazole, followed by spectrophotometric determination in food samples. Spiked recoveries ranged from 88.5% to 97.0%, with relative standard deviation (RSD) of

我们通过将表面分子印迹技术与溶胶 - 凝胶工艺相结合，制备了一种基于纳米粒子的甲硝唑印迹聚合物。以甲硝唑为模板，3 - 氨丙基三乙氧基硅烷为功能单体，正硅酸四乙酯为交联剂。通过傅里叶变换红外光谱、粉末X射线衍射和扫描电子显微镜对所得的磁性分子印迹聚合物进行了表征。该吸附剂可应用于甲硝唑的固相萃取，具有高吸附容量、良好的选择性、良好的重复使用性以及磁分离特性。通过平衡再结合实验和斯卡查德分析对吸附剂的结合性能进行了评估。该材料成功应用于甲硝唑的固相萃取，随后用于食品样品中的分光光度测定。加标回收率在88.5%至97.0%之间，相对标准偏差（RSD）为……