Influence of oryzanol and ferulic Acid on the lipid metabolism and antioxidative status in high fat-fed mice.

Influence of oryzanol and ferulic Acid on the lipid metabolism and antioxidative status in high fat-fed mice.

The comparative effects of oryzanol and ferulic acid on the lipid metabolism and antioxidative status of high fat-fed mice were investigated. The mice were given a diet containing 17% fat (HF), supplemented with oryzanol (HF-O) or ferulic acid for 7 weeks. The control mice (NC) were fed with normal diet. The HF mice exhibited increased body weight gain, plasma and hepatic total cholesterol and triglyceride concentrations, and lipid peroxidation rate, and reduced high-density lipoprotein cholesterol level. In general, they also showed lower hepatic antioxidant and higher lipid-regulating enzymes activities relative to that of NC group. Addition of oryzanol or ferulic acid in the diet counteracted these high fat-induced hyperlipidemia and oxidative stress via increased faecal lipid excretion and regulation of antioxidant and lipogenic enzymes activities. This study illustrates that oryzanol and ferulic acid have relatively similar hypolipidemic actions and could be effective in lowering the risk of high fat diet-induced obesity.

研究了谷维素和阿魏酸对高脂喂养小鼠脂质代谢和抗氧化状态的比较影响。给小鼠喂食含17%脂肪的饮食（高脂组，HF），并补充谷维素（HF - O组）或阿魏酸，持续7周。对照小鼠（正常对照组，NC）喂食正常饮食。高脂组小鼠体重增加、血浆和肝脏总胆固醇及甘油三酯浓度升高，脂质过氧化速率加快，高密度脂蛋白胆固醇水平降低。总体而言，与正常对照组相比，它们还表现出肝脏抗氧化能力降低以及脂质调节酶活性升高。在饮食中添加谷维素或阿魏酸通过增加粪便脂质排泄以及调节抗氧化和脂肪生成酶的活性，抵消了这些高脂肪诱导的高脂血症和氧化应激。这项研究表明，谷维素和阿魏酸具有相对相似的降血脂作用，并且可以有效降低高脂肪饮食诱导的肥胖风险。