Computed tomography-guided percutaneous biopsy for retroperitoneal lesions: a systematic review and meta-analysis

Computed tomography-guided percutaneous biopsy for retroperitoneal lesions: a systematic review and meta-analysis

Abstract The aim of this study is to perform a systematic review and meta-analysis of published studies to evaluate the efficacy and safety of computed tomography (CT)-guided percutaneous biopsy for retroperitoneal lesions. PubMed and the Cochrane Library were searched for English-language articles published up to October 2021 and reporting findings about patients with retroperitoneal lesions who underwent CT-guided percutaneous biopsy. The outcome measures assessed in this systematic review and meta-analysis are accuracy, false negative rate, and rate of minor and major complications. Heterogeneity among studies was evaluated by testing Cochran’s Q and the inconsistency index statistics. Seven studies published from 1975 to 2021 were selected for the analysis of accuracy, false negative rates, and rate of major and minor complications. The pooled accuracy of CT-guided percutaneous biopsy for retroperitoneal lesions was 93.6% [95% confidence interval (CI), 88.1–96.6%], with high heterogeneity. The pooled false negative rate was 6.3% (95% CI, 3.3–11.7%) with high heterogeneity. Pooled rates of minor and major complications were 3.7% (95% CI, 1.6–8.6%) with moderate heterogeneity and 0.7% (95% CI, 0.4–1.1%) with low heterogeneity, respectively. CT-guided percutaneous biopsy for retroperitoneal lesions has been reported to have high accuracy with a limited rate of major complications.

摘要：本研究的目的是对已发表的研究进行系统综述和荟萃分析，以评估计算机断层扫描（CT）引导下经皮穿刺活检对腹膜后病变的有效性和安全性。在PubMed和Cochrane图书馆中检索了截至2021年10月发表的英文文章，这些文章报道了接受CT引导下经皮穿刺活检的腹膜后病变患者的研究结果。本系统综述和荟萃分析所评估的结果指标为准确性、假阴性率以及轻微和严重并发症的发生率。通过检验Cochran's Q和不一致性指数统计量来评估研究间的异质性。选择了1975年至2021年发表的7项研究，用于分析准确性、假阴性率以及严重和轻微并发症的发生率。CT引导下经皮穿刺活检对腹膜后病变的汇总准确性为93.6%[95%置信区间（CI），88.1 - 96.6%]，具有高度异质性。汇总假阴性率为6.3%（95%CI，3.3 - 11.7%），具有高度异质性。轻微和严重并发症的汇总发生率分别为3.7%（95%CI，1.6 - 8.6%），具有中度异质性，以及0.7%（95%CI，0.4 - 1.1%），具有低度异质性。据报道，CT引导下经皮穿刺活检对腹膜后病变具有较高的准确性，且严重并发症的发生率有限。