Loss of Lkb1 impairs Treg function and stability to aggravate graft-versus-host disease after bone marrow transplantation

Loss of Lkb1 impairs Treg function and stability to aggravate graft-versus-host disease after bone marrow transplantation

Accumulating evidence suggests that a reduction in the number of Foxp3 + regulatory T cells (Tregs) contributes to the pathogenesis of acute graft-versus-host disease (aGVHD), which is a major adverse complication that can occur after allogeneic hematopoi

越来越多的证据表明，Foxp3 +调节性T细胞（Tregs）数量的减少有助于急性移植物抗宿主病（aGVHD）的发病机制，急性移植物抗宿主病是异基因造血（这里句子似乎不完整，最后一个单词“hematopoi”可能是“hematopoietic”相关的词，比如“hematopoietic stem cell transplantation”异基因造血干细胞移植等，如果有完整的句子会更好翻译准确）后可能发生的一种主要不良并发症。