喵ID：5v4YCN
Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Agouti C57BL/6N embryonic stem cells for mouse genetic resources.
Agouti C57BL/6N embryonic stem cells for mouse genetic resources.
Agouti C57BL/6N embryonic stem cells for mouse genetic resources.基本信息
DOI：
10.1038/nmeth.1342
10.1038/nmeth.1342发表时间：
2009-07
2009-07影响因子：
48
48通讯作者：
Skarnes, William C.
Skarnes, William C.中科院分区：
生物学1区
生物学1区文献类型：
Journal Article
Journal Article 作者： Pettitt, Stephen J.;Liang, Qi;Rairdan, Xin Y.;Moran, Jennifer L.;Prosser, Haydn M.;Beier, David R.;Lloyd, Kent C.;Bradley, Allan;Skarnes, William C.
研究方向： Biochemistry & Molecular Biology
MeSH主题词： --
关键词： --
来源链接：pubmed详情页地址
文献摘要
We report the characterization of a highly germline competent C57BL/6N mouse embryonic stem cell line, JM8. To simplify breeding schemes, the dominant Agouti coat color gene was restored in JM8 cells by targeted repair of the C57BL/6 nonagouti mutation. These cells provide a robust foundation for large-scale mouse knockout programs that aim to provide a public resource of targeted mutations in the C57BL/6 genetic background.
我们报道了一种具有高度生殖系能力的C57BL/6N小鼠胚胎干细胞系JM8的特性。为了简化繁殖方案，通过对C57BL/6非刺鼠毛色突变进行靶向修复，在JM8细胞中恢复了显性的刺鼠毛色基因。这些细胞为大规模小鼠基因敲除项目提供了坚实的基础，这些项目旨在为C57BL/6遗传背景下的靶向突变提供公共资源。
参考文献（20）
被引文献（289）
Improved generation of C57BL/6J mouse embryonic stem cells in a defined serum-free media
Improved generation of C57BL/6J mouse embryonic stem cells in a defined serum-free mediaDOI：
10.1002/gene.20031
10.1002/gene.20031发表时间：
2004-06-01
2004-06-01影响因子：
1.5
1.5作者：
Cheng, J;Dutra, A;Schwartzberg, PL
Cheng, J;Dutra, A;Schwartzberg, PL通讯作者：
Schwartzberg, PL
Schwartzberg, PLMUTATIONS AT AGOUTI LOCUS IN MOUSE
MUTATIONS AT AGOUTI LOCUS IN MOUSEDOI：
10.1093/oxfordjournals.jhered.a107920
10.1093/oxfordjournals.jhered.a107920发表时间：
1969-01-01
1969-01-01影响因子：
3.1
3.1作者：
DICKIE, MM
DICKIE, MM通讯作者：
DICKIE, MM
DICKIE, MMEstablishment and chimera analysis of 129/SvEv- and C57BL/6-derived mouse embryonic stem cell lines
Establishment and chimera analysis of 129/SvEv- and C57BL/6-derived mouse embryonic stem cell linesDOI：
10.2144/00295st04
10.2144/00295st04发表时间：
2000-11-01
2000-11-01影响因子：
2.7
2.7作者：
Auerbach, W;Dunmore, JH;Joyner, AL
Auerbach, W;Dunmore, JH;Joyner, AL通讯作者：
Joyner, AL
Joyner, ALLarge-scale gene trapping in C57BL/6N mouse embryonic stem cells
Large-scale gene trapping in C57BL/6N mouse embryonic stem cellsDOI：
10.1101/gr.078352.108
10.1101/gr.078352.108发表时间：
2008-10-01
2008-10-01影响因子：
7
7作者：
Hansen, Gwenn M.;Markesich, Diane C.;Abuin, Alejandro
Hansen, Gwenn M.;Markesich, Diane C.;Abuin, Alejandro通讯作者：
Abuin, Alejandro
Abuin, AlejandroMOLECULAR ANALYSIS OF REVERSE MUTATIONS FROM NONAGOUTI (A) TO BLACK-AND-TAN (A(T)) AND WHITE-BELLIED AGOUTI (A(W)) REVEALS ALTERNATIVE FORMS OF AGOUTI TRANSCRIPTS
MOLECULAR ANALYSIS OF REVERSE MUTATIONS FROM NONAGOUTI (A) TO BLACK-AND-TAN (A(T)) AND WHITE-BELLIED AGOUTI (A(W)) REVEALS ALTERNATIVE FORMS OF AGOUTI TRANSCRIPTSDOI：
10.1101/gad.8.4.481
10.1101/gad.8.4.481发表时间：
1994-02-15
1994-02-15影响因子：
10.5
10.5作者：
BULTMAN, SJ;KLEBIG, ML;WOYCHIK, RP
BULTMAN, SJ;KLEBIG, ML;WOYCHIK, RP通讯作者：
WOYCHIK, RP
WOYCHIK, RP共 18 条
- 1
- 2
- 3
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关联基金
High-throughput targeted mutagenesis of mouse stem cell lines
批准号：
7932973
7932973批准年份：
2006
2006资助金额：
468.75
468.75项目类别：
